Results 71 to 80 of about 29,630 (208)

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, EarlyView.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo. [PDF]

, 2015
Human cytomegalovirus (HCMV) causes significant morbidity in the immunocompromised host. Following primary infection, the virus establishes latent infection in progenitor cells of the myeloid lineage.

core   +1 more source

Validation of Digital Cytology for Primary Diagnosis Across a Range of Specimen Types

Cytopathology, EarlyView.
This single‐centre validation study demonstrated strong diagnostic concordance between high‐resolution whole‐slide imaging and traditional light microscopy across diverse cytology specimen types. Even with limited prior experience, pathologists found digital cytology feasible and acceptable for diagnostic use.
Talisa Mistry, Harriet Hunter, Dahmane Oukrif, Sabine Pomplun, Reena Khiroya, Mary Falzon, Tanya Alan, Manuel Rodriguez‐Justo, Adam P. Levine   +8 more
wiley   +1 more source

Cellularity of Routinely Prepared Cell Blocks: Insights From an International Study

Cytopathology, EarlyView.
This study revealed marked variability in the proportion of poorly cellular cell blocks among preparation methods and laboratories, highlighting the need for improved processing and regular monitoring of cell block adequacy. ABSTRACT Objective Formalin‐fixed, paraffin‐embedded (FFPE) cell blocks (CBs) are widely used for processing cytology specimens ...
Irena Srebotnik Kirbis, Ivana Kholova, Heini Huhtala, Margareta Strojan Flezar, Ruben Rodrigues Roque, Heli‐Hakso Mäkinen, Miisa Litmanen, Danijela Vrdoljak‐Mozetič, Suzana Harabajsa, Ekkehard Hewer, Enrica Bresaola, Lia Van Zuylen‐Manders, Pawel Schubert, Maria Praça, Esther Diana Rossi, Peter Karl Bode, Laetitia Lacoste‐Collin, Jessica Barizzi, Vincenzo Fiorentino, Tobias Hedegaard, Sietske van der Meulen, Ute Engel, Iris Timmer, Tugba Taskin Turkmenoglu, Jadranka Vidak, Elena Vigliar, Sonsoles Aso Manso, Jamal Musayev, Güliz A. Barkan, María D. Lozano, Ljube Ivkovski, Bettien van Hemel, Luca Carsana, Clementina Di Tonno, Birgit Weynand, Tania Labiano, Beatrix Cochand‐Priollet   +36 more
wiley   +1 more source

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
C Hubeau, RB Moss, P Reineck, AA Ionescu, LS Nixon, ME Poynter, P Delerive, SW Chung, BM Forman, W Wahli, JD Tugwood, JM Shipley, A Madej, JP Despres, N Marx, B Staels, Z Israelian-Konaraki, A Trifilieff, MA Birrell, M Roulet, PM Farrell, AP Sampson, JT Zakrzewski, J Carlstedt-Duke, SD Freedman, SM Loitsch, KA Kreuzer, JL Su, JD Dignam, TP Dean, K Balough, TZ Khan, A Augarten, F Akbiyik, I Inoue, DC Jones, P Greally, E Dagli, TA Waldmann, JH Parmentier, K Beier, C Andersson, M Ollero, H Pall, G Chinetti, PR Devchand, N Marx, AE Lovett-Racke, A Linden, F McAllister, RB Moss, RB Moss, C Hubeau, RU Sorensen   +53 more
core   +1 more source

Successful in vitro propagation of feline coronavirus from clinically diagnosed feline infectious peritonitis cases using Vero cells: A potential model for future research

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Feline coronavirus (FCoV) causes inapparent to progressive fatal feline infectious peritonitis (FIP) in domestic and wild cats, which affects multiple‐organ systems. Methods We investigated three clinically sick cats using different laboratory and molecular tests to diagnose and confirm FCoV and propagate the virus in Vero cell ...
Eaftekhar Ahmed Rana, Mahfuza Akther, Susan Beetson, Subir Sarker, Gabriele Rossi, Jasim M. Uddin   +5 more
wiley   +1 more source

Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7 [PDF]

, 2018
The excessive production of type I IFNs is a hallmark and a main pathogenic mechanism of many autoimmune diseases, including systemic lupus erythematosus (SLE).
Andreoli, Laura, Bergese, Paolo, Bosisio, Daniela, Busatto, Sara, D'Oro, Ugo, Giannello, Veronica, Salvi, Valentina, Sozzani, Silvano, Tincani, Angela, Zingoni, Alessandra   +9 more
core   +1 more source

Hallazgos del lavado broncoalveolar procesado con técnica de cytospin y citología convencional

Repertorio de Medicina y Cirugía, 2016
Actualmente la interpretación de la citología en lavado broncoalveolar (BAL) se realiza por medio de técnicas de citología convencional o en cytospin. Esta última obtiene preparaciones concentradas en un área de 6 mm para su visualización, con lo que se ...
José Fernando Polo, Victoria Elena Peña, Cristian Jair Pérez   +2 more
doaj  

Following damage, the majority of bone marrow-derived airway cells express an epithelial marker

Respiratory Research, 2006
Background Adult-derived bone marrow stem cells are capable of reconstituting the haematopoietic system. However there is ongoing debate in the literature as to whether bone marrow derived cells have the ability to populate other tissues and express ...
Webb Sheila, Edwards Carol J, Keir Pamela A, MacPherson Heather, Dorin Julia R   +4 more
doaj   +1 more source

High accuracy in detecting HER2‐low status in FNA of primary and metastatic breast cancer

Cancer Cytopathology, Volume 134, Issue 3, March 2026.
ABSTRACT Background HER2‐positive invasive breast carcinomas (IBCs) account for 15% of breast cancers and are driven by ERBB2 gene amplification. Although historically associated with aggressive behavior, HER2‐targeted therapies have significantly improved outcomes.
Giuseppe D’Abbronzo, Stefano Lucà, Immacolata Cozzolino, Marina Accardo, Carminia Della Corte, Francesco Iovino, Simona Parisi, Ilaria Tedesco, Francesco Ingallinella, Francesca Grasso, Renato Franco, Marco Montella   +11 more
wiley   +1 more source