Results 71 to 80 of about 30,637 (206)

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan   +12 more
wiley   +1 more source

Downregulation of Tumor Necrosis Factor Expression in the Human Mono-Mac-6 Cell Line [PDF]

, 1989
Mono-Mac-6 cells, but not U937 cells, can be Induced to rapidly express tumor necrosis factor (TNF) mRNA and protein when triggered with Ilpopolysaccharlde (LPS) at 1 pg/mI. Preincubatlon of the cells for 3 d with low amounts of LPS (10 ng/mI) results In
Blömer, Kathi, Haas, Jürgen G., Riethmüller, Gert, Thiel, Corinna, Weiss, Elisabeth H., Ziegler-Heitbrock, H. W. Löms   +5 more
core   +1 more source

Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Anthracyclines are among the most effective chemotherapeutic agents used to treat pediatric malignancies. However, their clinical use is limited by dose‐dependent toxicities, particularly cardiotoxicity and secondary malignancies.
Darleen S. Tu, Aaron K. Olson, Kimberly S. Waggie, Nicolas M. Garcia, Virginia J. Hoglund, Stephanie I. Walter, Jenna R. Rosinski, Harini Sadeeshkumar, Radhika Patel, Erolcan Sayar, Michael C. Haffner, Lisa Maves, Jacques Neefjes, Jay F. Sarthy, Elizabeth R. Lawlor, Shireen S. Ganapathi   +15 more
wiley   +1 more source

Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells From Old Individuals Towards Senescent Fibroblasts

Aging Cell, Volume 25, Issue 2, February 2026.
Unrestrained Cdc42 activity causes failure of cytotoxic function of old NK cells. This is associated with disruption of microtubular network and impaired mitochondrial ATP resulting in reduced conjugation and impaired degranulation of lytic vesicles.
Albert Kallon Koroma, Karmveer Singh, Yongfang Wang, Linda Krug, Philipp Haas, Meinhard Wlaschek, Vadim Sakk, Tanja Schuster, Daniel Fürst, Hubert Schrezenmeier, Rashmi Priyadharshini Dheenadayalan, Stephan Stilgenbauer, Lutz Walter, Hartmut Geiger, Karin Scharffetter‐Kochanek, Pallab Maity   +15 more
wiley   +1 more source

Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]

, 2008
Cigarette smoke (CS)–induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David, March, Thomas H, Rahman, Irfan, Seagrave, JeanClare, Yao, Hongwei   +4 more
core   +2 more sources

NF‐κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor‐Resistant Cutaneous T‐Cell Lymphoma

Cancer Science, Volume 117, Issue 2, Page 407-417, February 2026.
We identified a novel mechanism of resistance to histone deacetylase inhibitors (HDACi) in cutaneous T‐cell lymphoma (CTCL), mediated by NF‐κB activation. This finding highlights NF‐κB as a potential therapeutic target for overcoming HDACi resistance in CTCL.
Yuto Takahashi, Akihiro Kitadate, Sayaka Iwama, Wataru Kuroki, Ko Abe, Masahiro Yamada, Sho Ikeda, Hiroyuki Tagawa, Hideki Wakui, Masaki Hikida, Naoto Takahashi   +10 more
wiley   +1 more source

Immunocytochemical Phenotyping of Disseminated Tumor Cells in Bone Marrow by uPA Receptor and CK18: Investigation of Sensitivity and Specificity of an Immunogold/Alkaline Phosphatase Double Staining Protocol [PDF]

, 1997
Phenotyping of cytokeratin (CK) 18-positive cells in bone marrow is gaining increasing importance for future prognostic screening of carcinoma patients. Urokinase-type plasminogen activator receptor (uPA-R) is one example of a potential aggressive marker
Allgayer, Heike, Babic, Rudolf, Heiss, Markus Maria, Jauch, Karl-Walter, Riesenberg, Rainer, Schildberg, Friedrich Wilhelm   +5 more
core   +1 more source

Associations between clinical signs, endoscopic and cytological findings in equine bronchoalveolar lavage samples

Equine Veterinary Education, Volume 38, Issue 2, Page 101-108, February 2026.
Summary Background Endoscopy, including tracheal mucus score (TMS) and bronchoalveolar lavage (BAL) fluid cytology, is commonly employed in the diagnosis of equine asthma (EA). Large‐scale studies comparing clinical signs, TMS and BAL cytology are warranted.
M. Larsen, C. Amstrup, J. Fjeldborg, N. D. Otten, K. E. Baptiste, S. Hansen   +5 more
wiley   +1 more source

Hallazgos del lavado broncoalveolar procesado con técnica de cytospin y citología convencional

Repertorio de Medicina y Cirugía, 2016
Actualmente la interpretación de la citología en lavado broncoalveolar (BAL) se realiza por medio de técnicas de citología convencional o en cytospin. Esta última obtiene preparaciones concentradas en un área de 6 mm para su visualización, con lo que se ...
José Fernando Polo, Victoria Elena Peña, Cristian Jair Pérez   +2 more
doaj  

Induced sputum is a reproducible method to assess airway inflammation in asthma

Mediators of Inflammation, 2002
To evaluate the reproducibility of induced sputum analysis, and to estimate the sample size required to obtained reliable results, sputum was induced by hypertonic saline inhalation in 29 asthmatic subjects on two different days.
Elena Bacci, Silvana Cianchetti, Stefano Carnevali, Maria Laura Bartoli, Federico L. Dente, Antonella Di Franco, Daniele Giannini, Barbara Vagaggini, Pier Luigi Paggiaro   +8 more
doaj   +1 more source