Results 131 to 140 of about 842,255 (343)
Cytotoxic Activity of Isoantibody on Sarcoma 1.
Experimental Biology and Medicine, 1962 SummaryUnder favorable experimental conditions Sa 1 is completely sensitive to cytotoxic isoantibody in vitro. Similar results may also be obtained with small inocula of Sa 1 in vivo. In view of these results, it no longer seems possible to retain the past distinctions based on differences in isoantibody sensitivity between tumors of different origins.
Chourourlinkov, I, Boyse, E A, Old, L J
openaire +3 more sources
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera [PDF]
, 1979 Eiichi Nakayama +4 more
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Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Cytotoxic effects of selective species of Caryophyllaceae in Iran [PDF]
Research Journal of Pharmacognosy, 2014 Cancer is a major cause of death worldwide and causes serious problems in human life. It is developed by uncontrolled growth of a cell or a group of cells.
F. Naghibi +4 more
doaj
CYTOTOXIC ACTIVITY OF MOUSE MACROPHAGES STUDIED BY VARIOUS INHIBITORS [PDF]
, 1974 H Melsom
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Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
مجله علمی دانشگاه علوم پزشکی کردستان, 2022 Background and Aim: Chemotherapy is one of the most common methods available for the treatment of cancer. Resistance to anticancer drugs can result in failures in chemotherapy of cancers.
Touba Eslaminejad +5 more
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