Results 171 to 180 of about 745,289 (215)

Antibody drug conjugates beyond cytotoxic payloads.

Progress in Medicinal Chemistry, 2023
For many years, antibody drug conjugates (ADC) have teased with the promise of targeted payload delivery to diseased cells, embracing the targeting of the antibody to which a cytotoxic payload is conjugated. During the past decade this promise has started to be realised with the approval of more than a dozen ADCs for the treatment of various cancers ...
A. Hobson
semanticscholar   +3 more sources

Beyond cytotoxic potency: disposition features required to design ADC payload

Xenobiotica
1. Antibody-drug conjugates (ADCs) have demonstrated impressive clinical usefulness in treating several types of cancer, with the notion of widening of the therapeutic index of the cytotoxic payload through the minimisation of the systemic toxicity ...
Hao Sun, Larry C. Wienkers, Anthony Lee
semanticscholar   +3 more sources

Characterization of Disulfide Bond Rebridged Fab–Drug Conjugates Prepared Using a Dual Maleimide Pyrrolobenzodiazepine Cytotoxic Payload

ChemMedChem, 2019
We describe the characterization of antigen binding fragments (Fab)–drug conjugates prepared using a dual maleimide pyrrolobenzodiazepine dimer cytotoxic payload (SG3710). Pyrrolobenzodiazepine dimers, which are DNA cross‐linkers, are a class of payloads
Ben T Ruddle, R. Fleming, Herren Wu, Changshou Gao, N. Dimasi   +4 more
semanticscholar   +3 more sources

On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy.

Journal of the American Chemical Society
Antibody-drug conjugates (ADCs) for the treatment of cancer aim to achieve selective delivery of a cytotoxic payload to tumor cells while sparing normal tissue.
Pragya Adhikari, Guangmin Li, M. Go, Danielle Mandikian, Hanine Rafidi, Carl Ng, S. Anifa, Kevin Johnson, Linda Bao, Hilda Hernandez Barry, Rebecca K Rowntree, Nicholas Agard, Cong Wu, K. Chou, Donglu Zhang, K. Kozak, Thomas H. Pillow, Gail D Lewis, Shang-Fan Yu, C. Boswell, J. Sadowsky   +20 more
semanticscholar   +3 more sources

Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates.

Journal of Chromatography A, 2016
UV spectrophotometry is widely used to determine the molar extinction coefficients (MECs) of cytotoxic drugs as well as the drug antibody ratios (DARs) of antibody drug conjugates (ADCs). However, the unknown purity of a drug due to interfering impurities can lead to erroneous MECs and DARs.
Chunlei Wang, Sike Chen, Janet Caceres-Cortes, R. Huang, A. Tymiak, Yingru Zhang   +5 more
semanticscholar   +3 more sources

FDA approves ADC Therapeutics’ loncastuximab tesirine, ushering in a new cytotoxic payload

Nature Reviews Drug Discovery, 2021
Asher Mullard
semanticscholar   +2 more sources