Results 121 to 130 of about 2,670,296 (390)

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M., Altfeld, M., Brander, C., Cohen, D.E., Freedberg, K.A., Goulder, P.J.R., John, M., Johnston, M.N., Kalife, E.T., Le Gall, S., Lee, P.K., Lichterfeld, M., Mallal, S.A., Mothe, B.R., O'Sullivan, K.M., Rosenberg, E.S., Sette, A., Strick, D.A., Walker, B.D., Yu, X.G.   +19 more
core   +2 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection.

New England Journal of Medicine, 1997
BACKGROUND Early in human immunodeficiency virus type 1 (HIV-1) infection there is a decline in viral replication that has been attributed to host immunity, but the components of this response, particularly the ability of cytotoxic T lymphocytes to ...
L. Musey, J. Hughes, T. Schacker, T. Shea, L. Corey, L. Corey, M. McElrath, M. McElrath   +7 more
semanticscholar   +1 more source

Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse

Frontiers in Immunology, 2018
Cytotoxic immunity relies on specialized effector T cells, the cytotoxic T cells, which are endowed with specialized cytolytic machinery that permits them to induce death of their targets. Upon recognition of a target cell, cytotoxic T cells form a lytic
Anna Kabanova, Vanessa Zurli, Cosima Tatiana Baldari   +2 more
doaj   +1 more source

Porcine γδ T cells express cytotoxic cell-associated markers and display killing activity but are not selectively cytotoxic against PRRSV- or swIAV-infected macrophages

Frontiers in Immunology
BackgroundGamma-delta (γδ) T cells are a major immune cell subset in pigs. Approximately 50% of circulating T cells are γδ T cells in young pigs and up to 30% in adult sows.
Leonie Bettin, Leonie Bettin, Joseph Darbellay, Jill van Kessel, Neeraj Dhar, Neeraj Dhar, Neeraj Dhar, Volker Gerdts, Volker Gerdts   +8 more
doaj   +1 more source

Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. [PDF]

, 2019
Background: The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice.
Abraham, Tara S., Baybutt, Trevor R., Flickinger, John C., Hyslop, Terry, Kraft, Walter K., Sato, Takami, Snook, Adam E., Waldman, Scott A., Xiang, Bo, Zhan, Tingting   +9 more
core   +3 more sources

Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency [PDF]

, 2014
Defects in perforin lead to the failure of T and NK cell cytotoxicity, hypercytokinemia, and the immune dysregulatory condition known as familial hemophagocytic lymphohistiocytosis (FHL).
Alonso-Ferrero, ME, Arumugam, P, Baum, C, Blundell, MP, Carmo, M, Gaspar, HB, Hontz, AE, Jordan, MB, Malik, P, Montiel-Equihua, CA, Risma, KA, Schambach, A, Thrasher, AJ, Tiwari, S   +13 more
core   +2 more sources

Germline defects of familial hemophagocytic lymphohistiocytosis-related genes presenting as adult-onset peripheral T-cell lymphoma

Frontiers in Immunology
Germline mutations in genes involved in perforin-granzyme-mediated cytotoxicity such as PRF1, UNC13D, STX11, and STXBP2 were known to cause familial hemophagocytic lymphohistiocytosis (FHL).
Chong Wei, Danqing Zhao, Song Xue, Hao Cai, Congwei Jia, Daobin Zhou, Wei Zhang   +6 more
doaj   +1 more source

Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes [PDF]

, 2010
Keratinocytes expressing tumor or viral antigens can be eliminated by antigen-primed CD8 cytotoxic T cells. CD4 T-helper cells help induction of CD8 cytotoxic T cells from naive precursors and generation of CD8 T-cell memory.
Al-Daraji, Andrew M. Lew, Azukizawa, Barnden, Bedoui, Blachere, Bourgeois, Buckwalter, Castellino, Dunn, Feng, Fernando, Fischbein, Ford, Frazer, Fuse, Graham R. Leggatt, Hernandez, Hiroaki Azukizawa, Hogquist, Holcmann, Ian H. Frazer, Janssen, Jennifer K. Broom, Kenna, Kim, Lammermann, Matsumoto, McGargill, Mintern, Mintern, Mintern, Rosenberg, Salek-Ardakani, Schoenberger, Schuurhuis, Sha, Smith, Sun, Tony J. Kenna, Wakim, Wakim, Wang, Zhong, Zhong   +44 more
core   +2 more sources

Immunotherapy of Cytotoxic T Cell–resistant Tumors by T Helper 2 Cells

Journal of Experimental Medicine, 2003
Currently most attempts at cancer immunotherapy involve the generation of CD8+ cytotoxic T lymphocytes (CTLs) against tumor-associated antigens. Many tumors, however, have been immunoselected to evade recognition by CTLs and thus alternative approaches ...
J. Mattes, M. Hulett, Wei Xie, S. Hogan, M. Rothenberg, P. Foster, C. Parish   +6 more
semanticscholar   +1 more source