Results 61 to 70 of about 2,670,296 (390)

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

Journal of Immunology, 1994
The relationship between binding affinity for HLA class I molecules and immunogenicity of discrete peptide epitopes has been analyzed in two different experimental approaches. In the first approach, the immunogenicity of potential epitopes ranging in MHC
A. Sette, A. Vitiello, B. Reherman, P. Fowler, R. Nayersina, W. Kast, C. Melief, C. Oseroff, L. Yuan, J. Ruppert, J. Sidney, M. D. Guercio, S. Southwood, R. Kubo, R. Chesnut, H. Grey, F. Chisari   +16 more
semanticscholar   +1 more source

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.

Blood, 2013
Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α(+)DC are specialized to cross-prime CD8(+) T cells and produce interleukin-12 (IL-12) that promotes cytotoxicity.
G. Nizzoli, Jana Krietsch, Anja Weick, S. Steinfelder, F. Facciotti, P. Gruarin, Annalisa Bianco, B. Steckel, M. Moro, M. Crosti, C. Romagnani, K. Stölzel, S. Torretta, L. Pignataro, C. Scheibenbogen, P. Neddermann, R. de Francesco, S. Abrignani, J. Geginat   +18 more
semanticscholar   +1 more source

The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I [PDF]

, 2006
The major histocompatibility complex (MHC) class I region in mammals contains both classical and non-classical MHC class I genes. Classical MHC class I molecules present antigenic peptides to cytotoxic T lymphocytes, whereas non-classical MHC class I ...
Anderson, Araibi, Ashrafi, Ashrafi, Ashrafi, B. Marchetti, Borrego, Cohen, Davies, Di Palma, E.H. Araibi, E.S. Dornan, Ellis, Ellis, Ellis, Frazer, G.H. Ashrafi, Geraghty, Hofmeister, M. Dobromylskyj, M.S. Campo, Marchetti, Marchetti, McQueen, O'Brien, Pennie, Piguet, Pizzato, Riteau, Roeth, S.A. Ellis, Storset, Storset, Tindle, Tomasec, Toye, Wang, Williams   +37 more
core   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Next-Generation Immunotherapies to Improve Anticancer Immunity

Frontiers in Pharmacology, 2021
Checkpoint inhibitors are widely used immunotherapies for advanced cancer. Nonetheless, checkpoint inhibitors have a relatively low response rate, work in a limited range of cancers, and have some unignorable side effects.
Yaoyao Shi, Katarzyna Tomczak, June Li, Joshua K. Ochieng, Younghee Lee, Cara Haymaker   +5 more
doaj   +1 more source

Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis [PDF]

, 1976
Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL).
Bevan, Canty, Doherty, Doherty, Ertl, Forman, Gordon, Herberman, Koszinowski, Pfizenmaier, Pfizenmaier, Pfizenmaier, Shearer, Shreffler, Wagner, Wekerle, Zinkernagel   +16 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses [PDF]

, 2007
SummaryThe molecular mechanisms whereby the CD45 tyrosine phosphatase (PTPase) regulates T cell receptor (TCR) signaling responses remain to be elucidated.
Alexander, Denis R, Carret, Celine K, Cassady-Cain, Robin, Cooper, Joanne C, Holmes, Nick, McNeill, Louise, Roche-Molina, Marta, Salmond, Robert J., Tandon, Panna   +8 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source