Results 61 to 70 of about 823,721 (360)
Frontiers in ImmunologyEngineered T cell-based adoptive immunotherapies met promising success for the treatment of hematological malignancies. Nevertheless, major hurdles remain to be overcome regarding the management of relapses and the translation to solid tumor settings ...
Patricia Mercier-Letondal +10 more
doaj +1 more source
Capacity of different cell types to stimulate cytotoxic T lymphocyte precursor cells in the presence of interleukin 2 [PDF]
, 1984 Plastic-adherent cells enriched for dendritic cells (AC) were found to be among the most potent stimulator cells for the activation of cytotoxic T lymphocytes (CTL) in vitro in the presence of interleukin 2 (IL 2) and a constant second set of allogeneic ...
Dröge, W. +6 more
core
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
In vivo OVA-specific Cytotoxic CD8+ T Cell Killing Assay
Bio-Protocol, 2016 Cytotoxic CD8+ T cells are responsible for the lysis of cells expressing peptides associated with MHC class I molecules and derived from infection with a pathogen or from mutated antigens.
Nada Chaoul +2 more
doaj +1 more source
Mitochondrial fatty acid oxidation is stimulated by red light irradiation
FEBS Letters, EarlyView.Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera +4 more
wiley +1 more source
MULTICOLOR FLOW CYTOMETRIC ANALYSIS OF CYTOTOXIC T CELL SUBSETS
Медицинская иммунология, 2016 Multiparameteric flow analysis has offered an ability of simultaneous analysis of multiple molecules at the single-cell level. Peripheral blood cells from 110 healthy subjects aged 18-65 years (59 males and 51 females) were stained with antibodies to CD3,
I. V. Kudryavtsev +4 more
doaj +1 more source
JCI Insight, 2022 Clinical outcomes in colorectal cancer (CRC) correlate with T cell infiltrates, but the specific contributions of heterogenous T cell types remain unclear.
Kazuya Masuda +20 more
doaj +1 more source
Acta Neuropathologica Communications, 2023 Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but also with ...
Ayse N. Menevse +30 more
doaj +1 more source
Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]
, 2013 It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren +3 more
core +1 more source
Cell Proliferation and Cytotoxicity Assays [PDF]
Current Pharmaceutical Biotechnology, 2016 Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms in action of certain genes, proteins and pathways involved cell survival or death after exposing to toxic agents.
Yağmur Kiraz, Aysun Adan, Yusuf Baran
openaire +3 more sources