Results 201 to 210 of about 216,752 (252)
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi +6 more
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Annals of the New York Academy of Sciences, 1988
We have used recombinant vaccinia viruses expressing the cloned genes coding for glycoprotein B (gB) or glycoprotein D (gD) of HSV-1 to analyze the role of HSV-1--specific cytotoxic T lymphocytes (CTL) in antiviral immunity. Various studies in mice revealed that either vector could stimulate some aspects of HSV-1--specific immunity, but surprisingly ...
S, Martin, E, Cantin, B T, Rouse
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We have used recombinant vaccinia viruses expressing the cloned genes coding for glycoprotein B (gB) or glycoprotein D (gD) of HSV-1 to analyze the role of HSV-1--specific cytotoxic T lymphocytes (CTL) in antiviral immunity. Various studies in mice revealed that either vector could stimulate some aspects of HSV-1--specific immunity, but surprisingly ...
S, Martin, E, Cantin, B T, Rouse
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Endocytosis in cytotoxic T-lymphocytes
Cellular Immunology, 1981Abstract Endocytosis in T lymphocytes was analyzed during their differentiation into cytotoxic effector cells in allogeneic mixed lymphocyte cultures. We found that endocytic activity increases from a very low value to reach a peak at Day 5, at which time the cytotoxic titer is highest in these cell cultures.
Heiniger, H J +2 more
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T lymphocytes with promiscuous cytotoxicity
Nature, 1976CYTOTOXIC T lymphocytes generated during a unidirectional mixed lymphocyte culture (MLC) lyse target cells which have the antigenic phenotype of the allogeneic stimulating cells. The cytotoxic effect is restricted to cells that bear the same major histocompatibility antigens (H–2 antigens in mice) as the stimulating cells1.
C, Shustik +4 more
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Cytotoxic T lymphocytes and autoimmunity
Current Opinion in Rheumatology, 2005The possibility of the recognition by cytotoxic T lymphocytes of tissue autoantigens has been largely ignored in explaining organ-specific autoimmune diseases. Recent advances in the understanding of human leukocyte antigen class I-binding peptides motifs have led to the detection and the characterization of those autoreactive CD8(+) cytotoxic T ...
Patrick, Blanco +3 more
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The lysis of cytotoxic T lymphocytes and their blasts by cytotoxic T lymphocytes.
Immunology, 1991After binding to their targets, cytotoxic T lymphocytes (CTL) deliver a lethal hit signal, ultimately leading to target cell lysis, and then can recycle to lyse additional targets, without themselves being destroyed. If non-specific secreted lytic mediators are involved in such lysis.
B, Schick, G, Berke
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The stepwise activation of cytotoxic T lymphocytes
Immunology Today, 1987The recognition of antigen is the first stage of T-lymphocyte maturation in vivo. Monoclonal antibodies directed against the T-cell receptor/CD3 complex and against other surface antigens can also provide this stimulus. Gianni Gromo and his colleagues are attempting to characterize the steps leading from this initial activation to full functional ...
G, Gromo +4 more
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Suppressor‐Cytotoxic T‐Lymphocyte Panniculitis
Pediatric Dermatology, 1986Abstract: A 3½‐year‐old girl had fever and nonsuppurative panniculitis. Biopsies revealed lobular lymphocytic panniculitis. An extensive evaluation of the patient for infectious and other systemic diseases yielded negative results. Although the number of peripheral T lymphocytes was normal, suppressor‐cytotoxic (0KT8) lymphocytes predominated in the ...
A R, Solomon +5 more
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Cytotoxic T lymphocytes in herpesvirus infections
Veterinary Immunology and Immunopathology, 1984A. INTRODUCTION B. MEASUREMENT OF CTL AND THEIR DIFFERENTIATION FROM OTHER FORMS OF CYTOTOXICITY 1. The chromium re lease assay 2. S p e c i f i c i t y con t ro l s 3. I d e n t i f i c a t i o n of e f f e c t o r c e l l s w i th a l l o a n t i s e r a 4. Ef fec t of i n h i b i t o r s on CTL 5. Target c e l l s C.
B T, Rouse, D W, Horohov
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Activation of Cytotoxic Function in T Lymphocytes
The Journal of Immunology, 1976Abstract The requirements for activation of cytotoxic function in mouse T lymphocytes were investigated. Initial generation of cytotoxicity in normal lymphocytes was equal in magnitude with either Con A or specific alloantigen, and in either case required DNA synthesis.
Heininger, D +3 more
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