Results 241 to 250 of about 358,425 (341)

Phase I/II clinical trial on the safety and preliminary efficacy of donor-derived anti-leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation: study rational and design. [PDF]

Front Immunol
Montagna D, Comoli P, Tanzi M, Montini E, Moretta A, Taurino G, Boghen S, Panigari A, Mina T, Giorgiani G, Del Fante C, Perotti C, Zecca M.   +12 more
europepmc   +1 more source

HLA class-I-transgenic mice as model system to study MHC-restricted antigen recognition in man [PDF]

, 1990
A. McMichael, C. Botteron, Chamberlain J-W, Dill O, E. H. Weiss, Engelhard V H, F. Kievits, G. Brem, G. Riethmüller, G. Schliesser, Kievits F, Kievits K, Krimpenfort P, Le A-T, P. Ivanyi, Pohla H, Taurog J D, Thurau S R, Weiss E H, Weiss E H   +19 more
core   +1 more source

Simian Immunodeficiency Virus (SIV)gagDNA-Vaccinated Rhesus Monkeys Develop Secondary Cytotoxic T-Lymphocyte Responses and Control Viral Replication after Pathogenic SIV Infection

, 2000
Michael A. Egan, William A. Charini, Marcelo J. Kuroda, Jörn E. Schmitz, Paul Rácz, Klara Tenner‐Racz, Kelledy Manson, Michael S. Wyand, Michelle A. Lifton, Christie E. Nickerson, Tong‐Ming Fu, John W. Shiver, Norman L. Letvin   +12 more
openalex   +2 more sources

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Reinvigoration of cytotoxic T lymphocytes in microsatellite instability-high colon adenocarcinoma through lysosomal degradation of PD-L1. [PDF]

Nat Commun
Liu D, Yan J, Ma F, Wang J, Yan S, He W.
europepmc   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

HIV-gag-specific cytotoxic T lymphocytes

Research in Immunology, 1989
Nixon, D, Mcmichael, A
openaire   +3 more sources

Identification of HLA-A*1101-restricted cytotoxic T lymphocyte epitopes derived from epidermal growth factor pathway substrate number 8

, 2016
Huifang Lu, Bai-Shan Tang, Yanjie He, Weijun Zhou, Jielei Qiu, Yuhua Li   +5 more
openalex   +2 more sources

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source