Results 261 to 270 of about 733,847 (374)

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

Advanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu   +13 more
wiley   +1 more source

Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes

, 1989
Jack F. Bukowski, I Kurane, C J Lai, M Bray, Barry Falgout, F A Ennis   +5 more
openalex   +1 more source

Inability of mice to generate cytotoxic T lymphocytes to vesicular stomatitis virus restricted to H-2Kk or H-2Dk. [PDF]

, 1981
Kenneth L. Rosenthal, Rolf M. Zinkernagel   +1 more
openalex   +1 more source

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

Advanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma, Lei Gao, Kewei Song, Baohong Gu, Bofang Wang, Yang Yu, Xueyan Wang, Xuemei Li, Jike Hu, Weigao Pu, Yunpeng Wang, Na Wang, Dedai Lu, Zhijian Han, Hao Chen   +14 more
wiley   +1 more source

Recovery from a viral respiratory tract infection. IV. Specificity of protection by cytotoxic T lymphocytes. [PDF]

, 1983
M A Wells, Sylvester Daniel, J Y Djeu, Susan C. Kiley, F A Ennis   +4 more
openalex   +1 more source

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

Advanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
wiley   +1 more source

Cytotoxic T lymphocyte hybridomas that mediate specific tumor-cell lysis in vitro.

, 1981
Yael Kaufmann, Gideon Berke, Zelig Eshhar   +2 more
openalex   +1 more source

The presence of NK alloantigens on cloned cytotoxic T lymphocytes. [PDF]

, 1983
C G Brooks, R C Burton, Sylvia B. Pollack, C S Henney   +3 more
openalex   +1 more source

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

Cancer Research, 2004
C. Garnett, C. Palena, Mala Chakarborty, K. Tsang, J. Schlom, J. Hodge   +5 more
semanticscholar   +1 more source