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Cytotoxic T lymphocytes against HIV
AIDS, 1990HIV-1 infection has clearly been shown to induce a vigorous CTL response in infected people, and this response is present at a time when immune function otherwise is globally impaired. HIV-1-specific CTL are detectable both in peripheral blood and tissues of infected people, and are aimed at multiple viral proteins.
B D, Walker, F, Plata
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T lymphocytes with promiscuous cytotoxicity
Nature, 1976CYTOTOXIC T lymphocytes generated during a unidirectional mixed lymphocyte culture (MLC) lyse target cells which have the antigenic phenotype of the allogeneic stimulating cells. The cytotoxic effect is restricted to cells that bear the same major histocompatibility antigens (H–2 antigens in mice) as the stimulating cells1.
C, Shustik +4 more
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Cytotoxic T lymphocytes and autoimmunity
Current Opinion in Rheumatology, 2005The possibility of the recognition by cytotoxic T lymphocytes of tissue autoantigens has been largely ignored in explaining organ-specific autoimmune diseases. Recent advances in the understanding of human leukocyte antigen class I-binding peptides motifs have led to the detection and the characterization of those autoreactive CD8(+) cytotoxic T ...
Patrick, Blanco +3 more
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Scandinavian Journal of Immunology, 1985
A limiting‐dilution system was established to measure the frequency of alloreactive cytotoxic T‐lymphocyte precursors (CTL‐p) in human peripheral blood T cells. Culture medium supple mented with recombinant interleukin‐2 enabled clonal expansion of all CTL‐p stimulated by allogeneic peripheral blood or spleen cells.
D, Kabelitz +3 more
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A limiting‐dilution system was established to measure the frequency of alloreactive cytotoxic T‐lymphocyte precursors (CTL‐p) in human peripheral blood T cells. Culture medium supple mented with recombinant interleukin‐2 enabled clonal expansion of all CTL‐p stimulated by allogeneic peripheral blood or spleen cells.
D, Kabelitz +3 more
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Cytotoxic T-Lymphocyte-, and Helper T-Lymphocyte-Oriented DNA Vaccination
DNA and Cell Biology, 2004DNA vaccines have advantages over other types of vaccines in that they can induce strong cellular immune responses, namely cytotoxic T lymphocytes (CTL) and helper T lymphocytes (Th). DNA vaccines are therefore considered a promising alternative to attenuated live vaccines in the field of infectious diseases.
Toshi, Nagata +4 more
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CD4 cytotoxic T lymphocyte differentiation
Biochimie, 1988In vitro allostimulated CD4+ human lymphocytes were cloned by micromanipulation and expanded for a short time in IL-2 conditioned medium. In the present study we observed that proliferative noncytotoxic cloned cells were able to acquire the specific cytolytic activity under some modification of the cloned cells restimulation cycle. We demonstrated that
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Allogeneic tumor-specific cytotoxic T lymphocytes
Cancer Immunology Immunotherapy, 1992We report the development of cytotoxic T lymphocytes specific for an allogeneic brain tumor in a rat model. DA strain cytotoxic T cell precursors stimulated by an allogeneic tumor (9L gliosarcoma) from the Fischer rat could generate a population of cytotoxic T lymphocytes that lysed the allogeneic 9L tumor but failed to lyse other targets, including ...
J M, Redd +3 more
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Killing Mechanisms of Cytotoxic T Lymphocytes
Physiology, 1998Cytotoxic T lymphocytes mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins (perforin, granzymes) and receptor-ligand binding of Fas/APO molecules. Death of target cells is characterized by either necrosis or apoptosis, depending on the killing mechanism used and on the metabolism of the target cell itself.
Peter, Groscurth, Luis, Filgueira
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Cytotoxic T lymphocytes in herpesvirus infections
Veterinary Immunology and Immunopathology, 1984A. INTRODUCTION B. MEASUREMENT OF CTL AND THEIR DIFFERENTIATION FROM OTHER FORMS OF CYTOTOXICITY 1. The chromium re lease assay 2. S p e c i f i c i t y con t ro l s 3. I d e n t i f i c a t i o n of e f f e c t o r c e l l s w i th a l l o a n t i s e r a 4. Ef fec t of i n h i b i t o r s on CTL 5. Target c e l l s C.
B T, Rouse, D W, Horohov
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