Results 321 to 330 of about 733,847 (374)
Some of the next articles are maybe not open access.
Killing Mechanisms of Cytotoxic T Lymphocytes
Physiology, 1998Cytotoxic T lymphocytes mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins (perforin, granzymes) and receptor-ligand binding of Fas/APO molecules. Death of target cells is characterized by either necrosis or apoptosis, depending on the killing mechanism used and on the metabolism of the target cell itself.
Luis Filgueira, Peter Groscurth
openaire +3 more sources
Lymphocyte-Mediated Cytotoxicity [PDF]
, 2010 1 Cytotoxic Lymphocytes 2 CTLs and NK Cell Morphology and Function 3 Killing 4 Composition of Cytolytic Granules of CTLs and NK Cells 5 Killer Cell Self-Protection 6 Target Cell Death 7 Role of Perforin in the Induction of CTL Activation 8 Perforin Function in Homeostasis 9 Homeostatic Function of Fas and Fas-L 10 ...
openaire +1 more source
Cytotoxic T lymphocytes in herpesvirus infections
Veterinary Immunology and Immunopathology, 1984A. INTRODUCTION B. MEASUREMENT OF CTL AND THEIR DIFFERENTIATION FROM OTHER FORMS OF CYTOTOXICITY 1. The chromium re lease assay 2. S p e c i f i c i t y con t ro l s 3. I d e n t i f i c a t i o n of e f f e c t o r c e l l s w i th a l l o a n t i s e r a 4. Ef fec t of i n h i b i t o r s on CTL 5. Target c e l l s C.
Barry T. Rouse, David W. Horohov
openaire +3 more sources
Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity
2003New functions are implicated for calreticulin, based on its release from cytotoxic NK and T cells. Calreticulin is the only one of six “KDEL” (Lys-Asp-Glu-Leu carboxy terminal) endoplasmic reticulum chaperone proteins present in cytotoxic granules of these lymphocytes.
Dorothy Hudig, Reza Karimi
openaire +2 more sources
Targeting and Activation of Cytotoxic Lymphocytes
2015Des anticorps heteroconjugues ont permis d'etudier et de moduler la specificite des cellules cytotoxiques in vivo et in vitro. Il faut determiner quel anticorps bispecifique sera capable in vivo de «cibler» certaines cellules cytotoxiques qui pourront avoir des applications ...
David M. Segal, Denis P. Snider
openaire +3 more sources
Cytotoxic T Lymphocytes in Resistance to Tuberculosis
1998Recent experimental evidence has suggested T cells recognizing antigens in the context of both classical MHC class I and nonclassical class I-like molecules contribute to protective responses against Mycobacterium tuberculosis (MTB) infection. Our aims were to characterize both types of T cells, and to explore the basis of communication between the ...
Barry R. Bloom +6 more
openaire +3 more sources
Cytotoxic lymphocyte‐mediated immunotherapy
Australian and New Zealand Journal of Medicine, 1995Abstract:Cytotoxic CD8+ T cells and NK cells play a role in the elimination of some viruses, graft rejection, antitumour responses, immuno regulation and some autoimmune diseases. The central importance of these cells in each of these immune responses and the therapeutic potential they offer, when effectively targeted, has justified continued interest ...
Mark J. Smyth, Michael H. Kershaw
openaire +3 more sources
The role of cytotoxicity in lymphocyte homeostasis
Current Opinion in Immunology, 2001Several human inherited immune disorders lead to the same fatal lymphoproliferative syndrome, called the hemophagocytic syndrome. Through defective perforin expression or transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in the regulation of the immune response and in lymphocyte homeostasis.
Alain Fischer +1 more
openaire +3 more sources
Cytotoxic lymphocytes in melanoma patients
International Journal of Cancer, 1972AbstractPeripheral blood lymphocytes from 61 melanoma patients were tested by a microcytotoxicity test for cell‐mediated immunity against melanoma cells. Lymphocytes from 13/25 patients were cytotoxic for autologous tumour cells, while lymphocytes from 31/56 patients were cytotoxic in the allogeneic situation.
J P, Faucault +3 more
openaire +3 more sources
Collaboration of helper and cytotoxic T lymphocytes
European Journal of Immunology, 1993AbstractCytotoxic T lymphocytes are major effector cells in responses to viral infections and in allograft rejection and are implicated in many other immunological reactions. Efficient induction of cytotoxic activity in these cells in many but not all cases depends upon helper Tand antigen‐presenting cells so that at least three different cell types ...
Peter Walden, Gemot Stuhler
openaire +3 more sources