Results 81 to 90 of about 733,847 (374)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to neoadjuvant chemotherapy [PDF]

, 2018
Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Borralho, Paula, Braga, Sofia, Cabral, M. Guadalupe, Jacinto, António, Saraiva, Diana P.   +4 more
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

CYTOTOXIC LYMPHOCYTES: THE ROLE IN INFLAMMATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATION AND REMISSION

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Despite the number of publications related to the expression of surface antigens of periphery blood lymphocytes in chronic obstructive pulmonary disease (COPD), algorithm for interpreting of the results and implicating pathogene-tic ...
N. A. Raspopina, E. G. Shuganov, F. N. Paleev, Zh. M. Salmasi, A. E. Shuganov   +4 more
doaj   +1 more source

Lymphocyte Cytotoxicity in Alcoholic Hepatitis

Gastroenterology, 1977
Studies were undertaken to evaluate the cytotoxicity of peripheral lymphocytes obtained from patients with alcoholic hepatitis. Lymphocyte cytotoxicity to Chang liver cells was investigated by a microcytotoxicity test, and that to autologous liver cells obtained by percutaneous liver biopsy was studied using a 51Cr release assay.
Carroll M. Leevy, Shinichi Kakumu
openaire   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Cytotoxic B Cells in Relapsing-Remitting Multiple Sclerosis Patients

Frontiers in Immunology, 2022
BackgroundEmerging evidence of antibody-independent functions, as well as the clinical efficacy of anti-CD20 depleting therapies, helped to reassess the contribution of B cells during multiple sclerosis (MS) pathogenesis.ObjectiveTo investigate whether ...
Vinícius O. Boldrini, Vinícius O. Boldrini, Ana M. Marques, Raphael P. S. Quintiliano, Adriel S. Moraes, Carla R. A. V. Stella, Carla R. A. V. Stella, Ana Leda F. Longhini, Ana Leda F. Longhini, Irene Santos, Marília Andrade, Breno Ferrari, Alfredo Damasceno, Rafael P. D. Carneiro, Rafael P. D. Carneiro, Carlos Otávio Brandão, Carlos Otávio Brandão, Alessandro S. Farias, Alessandro S. Farias, Alessandro S. Farias, Alessandro S. Farias, Leonilda M. B. Santos, Leonilda M. B. Santos   +22 more
doaj   +1 more source

Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections

Molecular Therapy, 2012
Severe and fatal viral infections remain common after hematopoietic stem cell transplantation. Adoptive transfer of cytotoxic T lymphocytes (CTLs) specific for Epstein–Barr virus (EBV), cytomegalovirus (CMV), and adenoviral antigens can treat ...
U. Gerdemann, J. Keirnan, U. Katari, R. Yanagisawa, A. Christin, L. Huye, S. Perna, Sravya Ennamuri, S. Gottschalk, M. Brenner, H. Heslop, C. Rooney, A. Leen   +12 more
semanticscholar   +1 more source

Anti-tumour therapeutic efficacy of OX40L in murine tumour model [PDF]

, 2004
OX40 ligand (OX40L), a member of TNF superfamily, is a co-stimulatory molecule involved in T cell activation. Systemic administration of mOX40L fusion protein significantly inhibited the growth of experimental lung metastasis and subcutaneous (s.c ...
Akiba, Ali, Ali, Bretscher, Carreno, Claire Entwisle, Cornelia S. McLean, Croft, Esther Choolun, Geng Li, Gramaglia, Gramaglia, Gruss, Guinan, Hellstrom, Imura, June Lynam, Kashii, Kjaergaard, Kjaergaard, Maxwell, Morris, Murrium Ahmad, Murtaza, Oh, Pan, Peter Loudon, Petty, Robert C. Rees, Rogers, Selman A. Ali, Shahid Mian, Smith, Stephanie E.B. McArdle, Stuber, Stuber, Todryk, Vetto, Wang, Weinberg, Weinberg, Weinberg, Weinberg, Whittle   +43 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source