Results 151 to 160 of about 686,731 (316)
Current Therapeutic Research, 2021 : Background: In Southeast Asia, Gynura procumbens has been utilized as a traditional medicinal herb for many diseases. The nontoxic effects of the leaves of G procumbens can be consumed safely for the treatment of many diseases, especially diabetes ...
Md. Ziaul Amin, Ph.D. +5 more
doaj
QUANTITATIVE STUDIES OF THE SENSITIVITY OF NORMAL AND NEOPLASTIC MOUSE CELLS TO THE CYTOTOXIC ACTION OF ISOANTIBODIES [PDF]
, 1962 Erna Möller, Göran Möller
openalex +1 more source
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu +4 more
wiley +1 more source
Computational Inference Methods for HIV-1 Selective Sweeps Shaped by Early Cytotoxic T-Lymphocyte Response [PDF]
arXiv, 2012 In this work we develop a stochastic model of acute HIV infection, based on the well-known standard model, that allows us to simulate the complex mutation pathways of HIV escape from multiple CTL responses. Under this model, we describe two computational inference methods. In one, we use a Bayesian approach to construct posteriors for the parameters of
arxiv
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM [PDF]
, 1960 Stanley Cohen
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Cytotoxic Granule Endocytosis in Primary Mouse Cytotoxic T Lymphocytes [PDF]
, 2016 Zytotoxische T Lymphozyten (CTLs) bekämpfen Infektionen, indem sie virusinfizierte oder entartete Zellen eliminieren. CTLs identifizieren ihre Zielzellen mit Hilfe spezifischer T-Zell Rezeptoren, was zur Ausbildung eines Zell-Zell-Kontaktes, der sogenannten Immunologischen Synapse, führt. An dieser IS erfolgt letztlich die Fusion zytotoxischer Granula (
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie +4 more
wiley +1 more source