Results 131 to 140 of about 709,234 (313)

In vitro Cytotoxicity of Selected Medicinal Plant Extracts used for the Management of Gastroenteritis in Northern Namibia, and their Antibacterial Activity against Multidrug-resistant Pathogens

Journal of Pure and Applied Microbiology
The global challenge of antibiotic resistance among gastrointestinal pathogens is increasing daily. Gastroenteritis is a major health challenge in developing countries and is ranked 8th among the top 10 causes of death in Namibia.
Albertina Mariina Ndinelao Shatri, Davis Ropafadzo Mumbengegwi   +1 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Production of Transgenic Cloned Miniature Pigs with Membrane-bound Human Fas Ligand (FasL) by Somatic Cell Nuclear Transfer

, 2010
Cell-mediated xenograft rejection, including NK cells and CD8+ CTL, is a major obstacle in successful pig-to-human xenotransplantation. Human CD8+ CTL and NK cells display high cytotoxicity for pig cells, mediated at least in part by the Fas/FasL pathway.
Kwang Wook Park, Soo Hyun Kim, Jae Young Heo, Seung Pyo Hong, Ji Yeon Yoo, Yun Jin Yun, Ki Myung Choi, Young Chul Park, Jae Goo Seol, Dong-Il Jin   +9 more
core  

cytotoxic

Citation: 'cytotoxic' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13071 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Cytotoxicity of gold nanoclusters in human liver cancer cells

, 2014
Yanjie Yang,1,2 Jing Nan,3 Jianwen Hou,3 Bianfei Yu,1 Tong Zhao,1 Shuang Xu,1 Shuangyu Lv,2 Haixia Zhang1 1Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, 2School of Medicine, Henan ...
Hou J, Yang Y, Yu B, Zhang H, Xu S, Lv S, Zhao T, Nan J   +7 more
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Cytotoxicity and antibacterial activity of gold-supported cerium oxide nanoparticles

, 2014
K Suresh Babu,1,† M Anandkumar,1,† TY Tsai,2 TH Kao,2 B Stephen Inbaraj,2 BH Chen2,31Centre for Nano Sciences and Technology, Madanjeet School of Green Energy Technologies, Pondicherry University, Kalapet, India; 2Department of Food Science,
Tsai TY, Suresh Babu K, Chen BH, Stephen Inbaraj B, Anandkumar M, Kao TH   +5 more
core