Results 121 to 130 of about 1,629,625 (355)

Heterocycles and a Sorbicillinoid from the Coral-Derived Fungus Penicillium chrysogenum

Marine Drugs
A detailed chemical study of the culture of a coral-derived fungus Penicillium chrysogenum resulted in the isolation and identification of four new aromatic heterocycles chrysoquinazolinones A–B (1–2) and chrysobenzothiazoles A–B (3–4), along with a new ...
Junjie Yang, Yuan Zong, Cili Wang, Kai Li, Yue Zhang, Pinglin Li   +5 more
doaj   +1 more source

CD56 in the Immune System: More Than a Marker for Cytotoxicity?

Frontiers in Immunology, 2017
Over the past years, the phenotypic and functional boundaries distinguishing the main cell subsets of the immune system have become increasingly blurred. In this respect, CD56 (also known as neural cell adhesion molecule) is a very good example.
H. Van Acker, A. Capsomidis, E. Smits, V. V. Van Tendeloo   +3 more
semanticscholar   +1 more source

Marked mitigation of transplant vascular sclerosis in FasL(gld) (CD95L) mutant recipients. I. The role of alloantibodies in the development of chronic rejection [PDF]

, 1999
Background. In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death.
Aitouche, A, Fung, JJ, Rao, AS, Salam, A, Starzl, TE, Subbotin, V, Sun, H, Valdivia, LA   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Paclitaxel-Loaded, Pegylated Carboxylic Graphene Oxide with High Colloidal Stability, Sustained, pH-Responsive Release and Strong Anticancer Effects on Lung Cancer A549 Cell Line

Pharmaceutics
Background: Graphene Oxide (GO) has shown great potential in biomedical applications for cancer therapeutics. The biosafety and stability issues of GO in biological media have been addressed by functionalization with polyethylene glycol (PEG).
Athina Angelopoulou, Myria Papachristodoulou, Efstathia Voulgari, Andreas Mouikis, Panagiota Zygouri, Dimitrios P. Gournis, Konstantinos Avgoustakis   +6 more
doaj   +1 more source

Antibacterial N-Arylcinnamamides as Anti-inflammatory Agents

Proceedings, 2019
A series of ring-substituted N-arylcinnamamides was prepared, characterized, and investigatedfor their antimicrobial efficacy in detail [...]
Jiri Kos, Lubos Danisovic, Zuzana Varchulova Novakova, Radoslav Zamborsky, Ferdinand Devinsky, Josef Jampilek   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Antitubercular Activity of 7-Methyljuglone-Loaded Poly-(Lactide Co-Glycolide) Nanoparticles

Pharmaceutics
Background/Objectives: Loading of natural products into poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as drug delivery systems for the treatment of diseases, such as tuberculosis (TB), has been widely explored.
Bianca Diedericks, Anna-Mari Kok, Vusani Mandiwana, Bhavna Gowan Gordhan, Bavesh Davandra Kana, Suprakas Sinha Ray, Namrita Lall   +6 more
doaj   +1 more source

The Cytotoxic Effect of Annona muricata Leaf Extract on Triple Negative Breast Cancer Cell Line

Proceedings, 2017
Annona muricata, also known as soursop, has been reported to show cytotoxic activities against cancer cell lines. In this study, we evaluated the antiproliferative effect of Annona muricata leaf extract on the triple negative breast cancer cell line (MDA-
Rana Kavurmacı, Serap Yalcin
doaj   +1 more source

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.

Cell Reports, 2017
PDL1 blockade produces remarkable clinical responses, thought to occur by T cell reactivation through prevention of PDL1-PD1 T cell inhibitory interactions.
M. Gato-Cañas, M. Zuazo, H. Arasanz, M. Ibáñez-Vea, L. Lorenzo, G. Fernández-Hinojal, R. Vera, C. Smerdou, E. Martišová, I. Arozarena, C. Wellbrock, Diana Llópiz, Marta Ruiz, P. Sarobe, K. Breckpot, G. Kochan, D. Escors   +16 more
semanticscholar   +1 more source