Results 101 to 110 of about 712,474 (313)
The Cytotoxic and Apoptotic Effects of Usnic Acid on Prostate Cancer versus Normal Cells
Proceedings, 2017 Prostate cancer (PC) is the most common epithelium-derived solid tissue cancer in males in developed countries. Lichen seconder metabolites have an important potential as new generation chemotherapeutics.
Işıl Ezgi Eryılmaz +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Cytotoxicity evaluation of alternative synthetic and natural antiparasitic compounds in the IPEC-J2 intestinal cell line [PDF]
embargoed_20280915Intestinal parasitic diseases represent an important problem, prevalent in developing countries. Increased carrier movement due to globalization, migration, and international travel has contributed to the increase of parasitic diseases ...
CHERVYAKOVA, NATALYA
core
Andrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity [PDF]
, 2019 Huiyuan Zhang,1 Weiwei Wang,1 Qian Du21Department of Neurology, Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, People’s Republic of China; 2EEG Room, Liaocheng People’s Hospital, Liaocheng, Shandong 252000, People’s ...
Du Q, Zhang H, Wang W
core
In vitro study on the biotransformation and cytotoxicity of three hexabromocyclododecane diastereoisomers in liver cells [PDF]
, 2016 In order to clarify the cytotoxicity of hexabromocyclododecane (HBCD) diastereoisomers, and to investigate the correlation of cytotoxicity and biotransformation of HBCDs, the immortalized human liver cells L02 and human hepatoma cells HepG2 were exposed ...
Chen, Cen +6 more
core +1 more source
InorganicsOrganometallic complexes of fac-tricarbonylrhenium have been shown to exhibit anticancer properties. Anthrapyrazole anticancer agents act as DNA intercalators and topoisomerase IIα inhibitors, leading to double-strand breaks (DBS) and cell cycle arrest ...
Georgios Paparidis +7 more
doaj +1 more source
Cytotoxicity of Corylifoliae Fructus. II. Cytotoxicity of Bakuchiol and the Analogues
YAKUGAKU ZASSHI, 1989 Bakuchiol is a major component of Corylifoliae Fructus (Psoralea corylifolia L.) and has been clarified to have cytotoxic activity. The chemical structure-cytotoxic activity relationship of bakuchiol was investigated by means of cytotoxic activity of synthesized analogues of bakuchiol and phenol.
J, Iwamura +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Poultry Science: In this study, we incorporated deletion of the O-antigen ligase gene to an attenuated Salmonella Enteritidis (SE) strain, JOL919 (SE PS; Δlon ΔcpxR), using the Lambda-Red recombination method and evaluated the safety and immunological aspects of the ...
Amal Senevirathne +2 more
doaj +1 more source