Results 91 to 100 of about 709,234 (313)
In vitro toxicological evaluation of pouched portioned oral nicotine products
Frontiers in ToxicologyIntroductionModern oral nicotine pouch products (ONPs) are a category of oral nicotine products which contain pharmaceutical-grade nicotine, flavors, and other food-grade ingredients but no tobacco leaf.
Brian M. Keyser +7 more
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The Cytotoxic and Apoptotic Effects of Usnic Acid on Prostate Cancer versus Normal Cells
Proceedings, 2017 Prostate cancer (PC) is the most common epithelium-derived solid tissue cancer in males in developed countries. Lichen seconder metabolites have an important potential as new generation chemotherapeutics.
Işıl Ezgi Eryılmaz +5 more
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Cytotoxicity of Corylifoliae Fructus. II. Cytotoxicity of Bakuchiol and the Analogues
YAKUGAKU ZASSHI, 1989 Bakuchiol is a major component of Corylifoliae Fructus (Psoralea corylifolia L.) and has been clarified to have cytotoxic activity. The chemical structure-cytotoxic activity relationship of bakuchiol was investigated by means of cytotoxic activity of synthesized analogues of bakuchiol and phenol.
J, Iwamura +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The cytotoxicity study of praziquantel enantiomers
, 2016 Qian Sun, Ruifeng Mao, Dongling Wang, Changyan Hu, Yang Zheng, Dequn Sun Department of Pharmacy, Marine College, Shandong University, Weihai, People’s Republic of China Abstract: Praziquantel (PZQ) is prescribed as a racemic mixture (racemic-PZQ,
Zheng Y +5 more
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InorganicsOrganometallic complexes of fac-tricarbonylrhenium have been shown to exhibit anticancer properties. Anthrapyrazole anticancer agents act as DNA intercalators and topoisomerase IIα inhibitors, leading to double-strand breaks (DBS) and cell cycle arrest ...
Georgios Paparidis +7 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The role of cytokines, coagulation and fibrinolysis in leucocyte and LAK cell cytotoxicity of tumour cells [PDF]
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Interleukin-2 activates lymphocytes to become highly cytotoxic for a wide range of tumour cell types in vitro (Iymphokine activated killer or LAK cells ...
Biggerstaff, John Patrick +1 more
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Cytotoxicity of lavender oil and its major components to human skin cells
, 2004 Lavender (Lavandula angustifolia) oil, chiefly composed of linalyl acetate (51%) and linalool (35%), is considered to be one of the mildest of known plant essential oils and has a history in wound healing.
Prashar, A., Evans, C.S., Locke, I.C.
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