Results 91 to 100 of about 805,987 (302)

Derivatives of Amodiaquine as Potent Human Cholinesterases Inhibitors: Implication for Treatment of Alzheimer’s Disease

Molecules
As some previously reported studies have proven that amodiaquine, in addition to its primary antimalarial activity, also has potential for new applications such as the inhibition of cholinesterases, in our study we focused on the evaluation of the ...
Ana Matošević, Dejan M. Opsenica, Marija Bartolić, Nikola Maraković, Andriana Stoilković, Katarina Komatović, Antonio Zandona, Suzana Žunec, Anita Bosak   +8 more
doaj   +1 more source

Analysis of the Cytotoxic Effects of Eryngium billardieri Delar. Extracts on MCF7 Cell Line

Proceedings, 2017
The Apiaceae (previously known as the Umbelliferae) is one of the largest plant families in the world. This family comprises approximately 450 genera and 3700 species worldwide.
Leyla Paşayeva, Esra Köngül, Rojen Geylan, Gökçe Şeker Karatoprak, Osman Tugay   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

In vitro toxicological evaluation of pouched portioned oral nicotine products

Frontiers in Toxicology
IntroductionModern oral nicotine pouch products (ONPs) are a category of oral nicotine products which contain pharmaceutical-grade nicotine, flavors, and other food-grade ingredients but no tobacco leaf.
Brian M. Keyser, Robert Leverette, Reagan McRae, John Wertman, Tom Shutsky, Ken Szeliga, Patrudu Makena, Kristen G. Jordan   +7 more
doaj   +1 more source

The Cytotoxic and Apoptotic Effects of Usnic Acid on Prostate Cancer versus Normal Cells

Proceedings, 2017
Prostate cancer (PC) is the most common epithelium-derived solid tissue cancer in males in developed countries. Lichen seconder metabolites have an important potential as new generation chemotherapeutics.
Işıl Ezgi Eryılmaz, Gamze Güney Eskiler, Beste Yurdacan, Ünal Egeli, Gülşah Çeçener, Berrin Tunca   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Synergistic cytotoxicity of homoharringtonine and etoposide in acute myeloid leukemia cells involves disrupted antioxidant defense

, 2019
Jingjing Zhang,1,* Huayun Geng,2,* Ling Liu,1 Hao Zhang1 1Department of Hematology, Affiliated Hospital of Jining Medical University, Jining 272029, Shandong Province, China; 2Department of Hematology, Dongchangfu People’s Hospital of Liaocheng ...
Liu L, Zhang J, Geng H, Zhang H
core  

Novel Tricarbonylrhenium-Anthrapyrazole Complexes with DNA-Binding and Antitumor Properties: In Vitro and In Vivo Pharmacokinetic Studies with ^99mTc-Analogue

Inorganics
Organometallic complexes of fac-tricarbonylrhenium have been shown to exhibit anticancer properties. Anthrapyrazole anticancer agents act as DNA intercalators and topoisomerase IIα inhibitors, leading to double-strand breaks (DBS) and cell cycle arrest ...
Georgios Paparidis, Melpomeni Akrivou, George Psomas, Ioannis S. Vizirianakis, Antonios Hatzidimitriou, Catherine Gabriel, Dimosthenis Sarigiannis, Dionysia Papagiannopoulou   +7 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The cytotoxicity study of praziquantel enantiomers

, 2016
Qian Sun, Ruifeng Mao, Dongling Wang, Changyan Hu, Yang Zheng, Dequn Sun Department of Pharmacy, Marine College, Shandong University, Weihai, People’s Republic of China Abstract: Praziquantel (PZQ) is prescribed as a racemic mixture (racemic-PZQ,
Zheng Y, Wang DL, Sun DQ, Sun Q, Hu CY, Mao RF   +5 more
core