Results 211 to 220 of about 1,629,625 (355)

Dual‐Layer Living Hydrogel Enables On‐Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy

Advanced Functional Materials, EarlyView.
A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao, Darine D'Adam, Anna Hu, Sixuan Zhang, Josua Roduner, Katharina Maniura‐Weber, Qun Ren   +6 more
wiley   +1 more source

An innovative treatment for lung cancer using gene-engineered human-induced pluripotent stem cell-derived natural killer cells. [PDF]

Cancer Immunol Immunother
Sato Y, Goto K, Yagishita S, Miyata K, Uesugi N, Torisawa YS, Naritomi Y, Takahashi R, Sho R, Takeno Y, Kurachi K, Yamada M, Higashi Y, Kimura H, Hamada A, Nishigaki F, Tamura K.   +16 more
europepmc   +1 more source

Bioinspired Stabilization of Fluorescent Au@SiO2 Tracers for Multimodal Biological Imaging

Advanced Functional Materials, EarlyView.
This study demonstrates a bioinspired stabilization strategy for fluorescent gold‐silica nanoparticles. Inspired by natural biosilica maturation, high‐temperature calcination transforms the silica shells, preventing dissolution in cell culture media and intracellular environments.
Wang Sik Lee, Henry Lee, Patricia Taladriz‐Blanco, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +5 more
wiley   +1 more source

CNS-compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity. [PDF]

Front Immunol
Asokan S, Zhou W, Fringuello A, Pointon T, Kennedy A, Freitas B, Tumas French J, Zhao H, Coughlan C, Alvarez E, Yu X.   +10 more
europepmc   +1 more source

Strain‐Programmable Luminescent Adhesive Patch With Tartrazine‐Mediated Optical Skin Clearing for Photochemical Tissue Bonding

Advanced Functional Materials, EarlyView.
We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim, Kyungjoo Jo, Kwanghyeon Park, Jun Hee Kim, Jong Hyeong Cho, Inhoo Choi, Sei Kwang Hahn   +6 more
wiley   +1 more source

A framework integrating multiscale in silico modeling and experimental data predicts CAR-NK cell cytotoxicity across target cell types. [PDF]

Proc Natl Acad Sci U S A
Ahmad S, Xing K, Pereira MSF, Castle S, Rajakaruna H, Nayak I, Stewart WC, Beckwith KA, Cairo MS, Naeimi Kararoudi M, Lee DA, Das J.   +11 more
europepmc   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Therapeutic potential of Brazilian medicinal plants and their metabolites. [PDF]

Genet Mol Biol
Serpeloni JM, Santos FVD, Tuttis K, Cólus IMS.   +3 more
europepmc   +1 more source

In Situ 3D Bioprinting: Impact of Cross‐Linking on the Adhesive Properties of Hydrogels

Advanced Functional Materials, EarlyView.
In situ 3D bioprinting enables the direct deposition of cell‐laden, adhesive biomaterials for on‐site tissue regeneration. This review provides a comprehensive overview of how cross‐linking influences the bioadhesive properties of hydrogels used in 3D bioprinting, highlighting cross‐linking triggers, bioadhesion mechanisms, polymer interpenetration ...
Odile Romero Fernandez, Mulazim Hussain Asim, Shumaila Arshad, Gergely Kali, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

High-content CRISPR activation screens identify synthetically lethal RNA-based mechanisms to sensitize cancer cells to targeted T cell cytotoxicity. [PDF]

Nat Genet
Akana RV, Yoe J, Laveroni O, Sun C, Kim YM, Jerby L.   +5 more
europepmc   +1 more source