Results 221 to 230 of about 805,987 (302)

Decoupling T cell cytotoxicity: a CCL21+ICAM1-based synthetic immune niche enhances tumor elimination by accelerating lytic hit delivery. [PDF]

BMC Cancer
Gupta MK, Zoabi R, Yado S, Starruß J, Geiger B, Hatzikirou H.   +5 more
europepmc   +1 more source

Leaftronics: Bio‐Fractal Scaffolds From Leaf Venation for Low‐Waste Electronics

Advanced Materials, EarlyView.
“Leaftronics” transforms naturally evolved leaf venation into quasi‐fractal scaffolds for sustainable electronics. Polymer‐infiltrated leaf skeletons can be used to fabricate ultra‐smooth, reflow‐ and thin‐film‐compatible decomposable substrates, while making the same lignocellulose networks conducting results in flexible transparent electrodes.
Rakesh Rajendran Nair, Hrisheekesh Thachoth Chandran, Karl Leo, Hans Kleemann   +3 more
wiley   +1 more source

JNJ-79032421, a Novel Membrane-Restricted Mesothelin-Targeting T Cell-Engaging Bispecific Antibody for the Treatment of Mesothelin-Positive Cancers. [PDF]

Mol Cancer Ther
Smans K, Nesspor T, De Breucker S, van Heerde E, Valckx A, Van Slycken N, Sproesser K, Cypert BM, Packman K, Chu G, Fisher J, Mazzanti N, Petley T, Chan W, Del Rosario B, Liu T, Ember S, Shaffer PL, Clawson JS, Bauml JM, Moores S, Laquerre S, Gavine PR.   +22 more
europepmc   +1 more source

Soft and Transient Bioelectronics Enabled by Polymer‐Free Ti3C2Tx MXene Hydrogels

Advanced Materials, EarlyView.
We present Ti3C2Tx MXene hydrogel (MXgel) bioelectronics, a soft, flexible, and fully transient platform for high‐fidelity neural recording and stimulation. MXgel bioelectronics exhibit exceptional electrical conductivities, low electrochemical impedances, and high charge injection capacities.
Raghav Garg, Franco A. Laimo, Stefano Ippolito, Prastuti Upadhyay, Spencer R. Averbeck, Dimitris Boufidis, Charles‐Antoine Assenmacher, Dayo O. Adewole, Sai Panigrahy, Bita Soltan Mohammadlou, Lucy Plant, Yuan Zhang, Andrew G. Richardson, Yury Gogotsi, D. Kacy Cullen, Flavia Vitale   +15 more
wiley   +1 more source

HDAC Inhibitors Potentiate Doxorubicin Cytotoxicity in HepG2 Cells and Alter DNA-Repair- and p53-Associated Transcriptional Programs. [PDF]

Int J Mol Sci
Guo K, van Herwijnen M, Caiment F, van den Beucken T.   +3 more
europepmc   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Biocidal Activity of Selected Essential Oils Against Bacterial and Fungal Pathogens and Their Cytotoxicity Toward Human Cell Lines. [PDF]

Microorganisms
Woźniak A, Drożdż K, Biegun-Drożdż K, Gosiewski T, Cudak T, Karpiński R, Fiołek A, Błoniarz A, Marchewka J, Moskalewicz T, Brzychczy-Włoch M.   +10 more
europepmc   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Generation of hypoimmunogenic cardiomyocytes from human induced pluripotent stem cells with TAPBP knockout. [PDF]

iScience
Yamamoto Y, Ohno R, Shoda K, Suzuki T, Momoi K, Fujii S, Kenmochi Y, Yoshikawa T, Shimomura M, Tsukamoto N, Ohnuki K, Tani H, Soma Y, Fukuda K, Nakatsura T, Tohyama S.   +15 more
europepmc   +1 more source