Results 161 to 170 of about 3,061,339 (237)

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Selection of laboratory assays for reliable assessment of complement-dependent cytotoxicity: impact of assay choice on CDC quantification. [PDF]

Front Immunol
Majeranowski A, Stasiłojć G, Panasiuk N, Okrój M.   +3 more
europepmc   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer. [PDF]

Cancer Cell
Campisi M, Osaki T, Dryg I, Stornante C, Wolff J, Weirather J, Weaver N, Tarannum M, Gillanders I, Bers A, Bobilev E, Lineberry MS, Schol P, Chen M, Ota K, Park SR, Fahey CG, Thai TC, Li Y, Li Z, Li ZH, Shelton S, Hirose S, Padrick C, Ivanova E, Ha M, Yang S, Olszewski H, Kivlehan S, Lizotte P, Hagen K, Gjeci I, Haller W, Zasadil LM, El Zarif T, Berchuck JE, Knelson EH, Brea EJ, Odintsov I, Liu T, Chiono V, Tuladhar B, Ngo K, Rosentrater E, Raizer J, Lineberry N, Sur M, Pfaff K, Freedman M, Hodi FS, Tolstorukov MY, Oser MG, Sheffer M, Mitsiades CS, Barnes MJ, Appleman VA, Gokhale PC, Kamm RD, Paweletz CP, Romee R, Rodig S, Barbie DA, Mahadevan NR.   +62 more
europepmc   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Irreversible Electroporation Enhances Solid Tumor Infiltration and Selective Cancer Cell Lysis by CAR T Cells. [PDF]

Clin Cancer Res
Vista WR, Malik V, Sheehan MC, Ismail J, Hocine HR, Ganbaatar U, Misawa K, Guzman Valle J, Banerjee S, Solomon SB, Adusumilli PS, Srimathveeravalli G.   +11 more
europepmc   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

PBMC-derive eNK cells was armed and promoted CAR-like response against tumors through armed with 16Fc21, a novel bispecific fusion protein for NK cells. [PDF]

Front Immunol
Li Y, Wang Y, Zhang X, Fan Y, Pan L, Wu J, Xiao W.   +6 more
europepmc   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Optimized <i>ex vivo</i> expansion and functional characterization of canine natural killer cells using genetically modified feeder cells. [PDF]

J Vet Sci
An Y, Kim GS, Baek Y, Park JH, Hong JW, Nguyen PQH, Kim SK.   +6 more
europepmc   +1 more source