Results 201 to 210 of about 13,946,192 (376)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno‐Free Cultures of Human Adipose Tissue‐Derived Stem Cells

Advanced Biology, EarlyView.
The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo, Anne Therese Lauvrud, Rebecca Wiberg, Maria Brohlin, Gustav Andersson, Paul J Kingham   +5 more
wiley   +1 more source

Rapid detection of cytotoxicity of food additives and contaminants by a novel cytotoxicity test, menadione-catalyzed H(2)O (2) production assay.

, 2001
Shiro Yamashoji, Kenji Isshiki
openalex   +2 more sources

Erratum to: Immortalized gingival fibroblasts as a cytotoxicity test model for dental materials [PDF]

, 2012
Rasika P. Illeperuma, Young J. Park, Jin M. Kim, Jung Yoon Bae, Mengjun Zhong, Hwa Kyung Son, Mi Ra Han, Kwang‐Mahn Kim, Jin Seok Kim   +8 more
openalex   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Interleukin-17A signaling promotes CD8+ T cell cytotoxicity against West Nile virus infection through enhancing PI3K-mTOR-mediated metabolism. [PDF]

PLoS Pathog
Nazneen F, Neupane B, Chen Y, Karim SU, You Z, Cui W, Bai F.   +6 more
europepmc   +1 more source

Histoincompatibility attributable to genes near H-2 that are not revealed by hemagglutination or cytotoxicity tests.

Transplantation, 1972
E. A. Boyse, L. Flaherty, E. Stockert, L. Old   +3 more
semanticscholar   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway. [PDF]

Nat Commun
Hitzler SUJ, Fernández-Fernández C, Günther K, Dietschmann A, Hovhannisyan H, Möslinger A, Austermeier S, Cristóvão B, Vascelli G, Zelante T, Pekmezović M, Ramírez-Zavala B, Morschhäuser J, Werz O, Gabaldón T, Jordan PM, Vylkova S, Gresnigt MS.   +17 more
europepmc   +1 more source

Original article Influence of serum and albumin on the in vitro anandamide cytotoxicity toward C6 glioma cells assessed by the MTT cell viability assay: implications for the methodology of the MTT tests [PDF]

, 2013
Krzysztof Bilmin, Beata Kopczyńska, Paweł Grieb   +2 more
openalex   +1 more source