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Error in cytotoxicity testing by cell lysis
Medical Microbiology and Immunology, 1974In cytotoxicity testing with murine lymphocytes, cytolysis, i.e. the complete loss of cell contours of the damaged and stained lymphocytes as a result of fluid influx, can cause considerable false negative titre determinations, as demonstrated by time-lapse microphotography. Under the usual test conditions, significant typing errors may be excpeted, if
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Cytotoxicity tests for high-throughput drug discovery
Current Opinion in Biotechnology, 2001Despite theoretical obstacles associated with performing cell-based assays in high-density formats (microplates with at least 384 wells), it is becoming clear that the pharmaceutical industry is now routinely running cell-based tests in these formats. This work is revealing the weakness of established cytotoxicity end points, specifically in relation ...
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Cytotoxic Food Testing in Alcoholics
Quarterly Journal of Studies on Alcohol, 1974G A, Ulett, E, Itil, S G, Perry
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Tests Predictive of Cytotoxic Activity
1974Tests predictive of cytotoxicity are of three general types; those that select agents for antitumor cytotoxicity, those that predict host cytotoxicity, and those applied to predict the toxicity/benefit ratio of a drug of generally accepted potency in a particular patient with a specific tumor.
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IMPROVED COMPLEMENTATION IN THE CYTOTOXIC TEST
Transplantation, 1970E A, Boyse +3 more
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Cytotoxic test for food intolerance.
Lancet (London, England), 1983P.G.S Fennell +2 more
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