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Error in cytotoxicity testing by cell lysis [PDF]
Medical Microbiology and Immunology, 1974 In cytotoxicity testing with murine lymphocytes, cytolysis, i.e. the complete loss of cell contours of the damaged and stained lymphocytes as a result of fluid influx, can cause considerable false negative titre determinations, as demonstrated by time-lapse microphotography. Under the usual test conditions, significant typing errors may be excpeted, if
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Clonogenic cytotoxicity testing by microdrop encapsulation
Nature, 1993Cytotoxicity is defined as the in situ measurement of cellular function in response to a toxic substance. Cytotoxicity assays are widely used in drug screening and development research to minimize the number of compounds on which expensive mammalian animal model toxicology studies are performed.
Nancy Kedersha, Blane Goguen
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, 1995
The bacterial bioluminescence assay is widely used to estimate chemical cytotoxicity. This assay is performed most often by using luminescent bacteria Vibrio fisheri NRRL-B-11177 (earlier cited as Photobacterium phosphoreum NRRL-B-11177) as a test ...
J. Lampinen, M. Virta, M. Karp
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The bacterial bioluminescence assay is widely used to estimate chemical cytotoxicity. This assay is performed most often by using luminescent bacteria Vibrio fisheri NRRL-B-11177 (earlier cited as Photobacterium phosphoreum NRRL-B-11177) as a test ...
J. Lampinen, M. Virta, M. Karp
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Cytotoxicity testing of a dentin bonding system
Oral Surgery, Oral Medicine, Oral Pathology, 1985The cytotoxicity of a newly developed dentin bonding system was examined in African green monkey kidney cells and human embryonic lung cells. A tissue culture agar overlay procedure, a longitudinal study, and a cell replication assay were employed to evaluate cytotoxicity.
Thom C. Dumsha, Robert J. Sydiskis
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Serial dilution microchip for cytotoxicity test [PDF]
Journal of Micromechanics and Microengineering, 2004 Today's pharmaceutical industry is facing challenges resulting from the vast increases in sample numbers produced by high-throughput screening (HTS). In addition, the bottlenecks created by increased demand for cytotoxicity testing (required to assess compound safety) are becoming a serious problem.
Young Kyung Lee +6 more
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Uridine uptake inhibition as a cytotoxicity test: Correlations with the Draize test
Toxicology, 1984The effects of 25 xenobiotic chemicals on the uptake of [3H]-uridine by Balb/c 3T3 cells were assessed. The test compounds, which included alcohols, ethers, esters, ketones, amides, acids and a detergent, inhibited uridine uptake at concentrations lower than those required to kill the cells; thus uridine uptake inhibition is a more sensitive indicator ...
Sonal Sathe, C. Shopsis
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Metabolizing systems in cell culture cytotoxicity tests.
Xenobiotica; the fate of foreign compounds in biological systems, 19881. The addition of 9000 g supernatant of rat liver homogenate (S9) or rat liver microsomal fractions to a cytotoxicity test system using BCL-D1 cells has been investigated. 2.
D. Benford, H. Reavy, S. Hubbard
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Cytotoxicity Testing: Cell Experiments
2011Screening for new anticancer agents has traditionally been done with in vitro cell culture methods. Even in the genomic era of target-driven drug design, screening for cytotoxic activity is still a standard tool in the search for new anticancer agents, especially if the mode of action of a substance is not yet known.
Aron F. Westendorf +5 more
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Cytotoxicity, Cytogenotoxicity and Allergenicity Tests on Certain Pyrethroids
Drug and Chemical Toxicology, 1987Pyrethroids are potent synthetic insecticides which have been increasingly employed in recent years. Such compounds have been shown to bind covalently to hepatic proteins. Covalent binding is often associated with toxic effects. Possible cytotoxic, cytogenotoxic and allergenic effects could be due to covalent binding of these compounds and/or their ...
H. Hoellinger +5 more
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Size-dependent cytotoxicity of gold nanoparticles.
Small, 2007Gold nanoparticles are widely used in biomedical imaging and diagnostic tests. Based on their established use in the laboratory and the chemical stability of Au(0), gold nanoparticles were expected to be safe.
Yu Pan +8 more
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