Results 31 to 40 of about 847,178 (247)
Monitoring the International Standardization Process Theoretical Choices and Methodological Tools [PDF]
Journal of Systemics, Cybernetics and Informatics, 2012 Many organizations are in charge of global security management. This paper outlines and argues for the construction of a theoretical and methodological framework in order to critically assess the new technopolitics currently being developed in the field ...
Brigitte Juanals, Jean-Luc Minel
doaj
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Sociologias, 2014 Quer se fale de "virada" ou de "imperativo" deliberativo, a democracia participativa está no bojo do tratamento dos problemas de meio ambiente, envolvendo o público.
Jean-Paul Billaud
doaj +3 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The use of nuclear data in the field of nuclear fuel recycling
EPJ Web of Conferences, 2017 AREVA NC La Hague facility is the first step of the nuclear fuel recycling process implemented in France. The processing of the used fuel is governed by high standards of criticality-safety, and strong expectations on the quality of end-products.
Martin Julie-Fiona +5 more
doaj +1 more source
Quaestio Rossica, 2014 В этой короткой статье мы рассматриваем, как при создании брендовой идентичности в постсоветской России происходит обращение к патриотическим чувствам потребителей. В рамках темы исследование ограничивается сферой алкогольной продукции.
Graham Roberts
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source