Results 41 to 50 of about 1,334,914 (244)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Materials & DesignAdaptive Spatial Lattice Manufacturing (ASLM) represents a groundbreaking method for fabricating lattice structures by leveraging AI-driven robotic laser welding. Unlike traditional additive manufacturing techniques, ASLM corresponds to a direct assembly
Justin Dirrenberger +4 more
doaj +1 more source
Monitoring the International Standardization Process Theoretical Choices and Methodological Tools [PDF]
Journal of Systemics, Cybernetics and Informatics, 2012 Many organizations are in charge of global security management. This paper outlines and argues for the construction of a theoretical and methodological framework in order to critically assess the new technopolitics currently being developed in the field ...
Brigitte Juanals, Jean-Luc Minel
doaj
Systematic discovery of anti-phage defense systems in the microbial pan-genome
Science, 2018 Maps of defense arsenals in microbial genomes To survive the attack of foreign invaders such as viruses and plasmids, bacteria and archaea fight back with immune systems that are usually clustered in “defense islands” in their genomes. Doron et al.
Shany Doron +7 more
semanticscholar +1 more source
Bacterial retrons function in anti-phage defense
bioRxiv, 2020 Retrons are bacterial genetic elements comprised of a reverse transcriptase (RT) and a non-coding RNA. The RT uses the non-coding RNA as a template, generating a chimeric RNA/DNA molecule in which the RNA and DNA components are covalently linked ...
A. Millman +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Phenylpropanoid Pathway Engineering: An Emerging Approach towards Plant Defense
Pathogens, 2020 Pathogens hitting the plant cell wall is the first impetus that triggers the phenylpropanoid pathway for plant defense. The phenylpropanoid pathway bifurcates into the production of an enormous array of compounds based on the few intermediates of the ...
V. Yadav +6 more
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Sociologias, 2014 Quer se fale de "virada" ou de "imperativo" deliberativo, a democracia participativa está no bojo do tratamento dos problemas de meio ambiente, envolvendo o público.
Jean-Paul Billaud
doaj +3 more sources