Results 41 to 50 of about 833,670 (244)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
La disonancia genérica en la comedia palatina temprana. El ejemplo de «Laura perseguida» (1594)
Anuario Lope de Vega: Texto, Literatura, Cultura, 2022 Laura perseguida es considerada generalmente como una comedia palaciega, pero la mezcla de características cómicas y trágicas hace difícil su definición precisa.
Christophe Couderc
doaj +1 more source
Une application pilote de simulation coopérative distribuée sous HLA (PRF SICODIS) [PDF]
, 2005 La modélisation et la simulation sont souvent employées par les chercheurs de l'ONERA, par les organismes de la Défense, par les industriels, pour concevoir et valider les systèmes complexes (systèmes de défense, systèmes d'information et de commandement,
Siron, Pierre
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Predicting Is Not Explaining: Targeted Learning of the Dative Alternation
Journal of Causal Inference, 2016 Corpus linguists dig into large-scale collections of texts to better understand the rules governing a given language. We advocate for ambitious corpus linguistics drawing inspiration from the latest developments of semiparametrics for a modern targeted ...
Chambaz Antoine, Desagulier Guillaume
doaj +1 more source
Divide and Sprawl, Decline and Fall: A Comparative Critique of Euclidean Zoning [PDF]
, 2007 As many commentators have pointed out, the land use patterns prevalent in the United States since the advent of Euclidean-style zoning have played a direct role in the development of a surprisingly broad range of problems: “[b]y fostering or requiring ...
Hall, Eliza
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Changes in the French Defence Innovation System: New roles and capabilities for the Government Agency for Defence. [PDF]
Defence innovation systems are structured around two main groups of players that interact in the development of complex programmes: the state (the client and the government agency) and the systems integrators.
Lazaric, Nathalie +2 more
core +3 more sources
La défense de provocation : une articulation des principes de détermination de la peine [PDF]
, 2012 Ce mémoire aborde la question des fondements moraux de la défense de provocation. Les concepts actuellement utilisés pour analyser ces fondements sont habituellement ceux de justification et d'excuse.
Simard, Jimmy
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source