Results 101 to 110 of about 798,630 (244)
Rattrapage vaccinal chez les enfants migrants: évaluation à l'indication de sérologies vaccinales [PDF]
, 2015 Les modalités de rattrapage vaccinal des patients migrants ont beaucoup évolué en Suisse ces dernières années. La couverture vaccinale de base s'est fortement répandue à travers le monde, rendant obsolète les schémas de revaccination complète.
EL HOUSS, S.
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Promotion de la santé et prévention des maladies chroniques au CanadaIntroductionLes inégalités raciales en matière de santé s’expliquent par une inégalité d’accès aux conseils médicaux et aux traitements ainsi que par les effets physiologiques des inégalités dans les conditions matérielles et la vie ...
Margaret Jamieson +3 more
doaj +1 more source
2019 CHA Elections Results / Résultats de l’élection 2019 de la SHC [PDF]
, 2019 Again this year, CHA members could choose from a list of well-qualified candidates for the elections. The CHA is proud to introduce its newest Council and Nominating Committee members as well as its student representative.Encore une fois cette année, les
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Open BiologyMisprocessing of amyloid precursor protein (APP) is one of the major causes of Alzheimer’s disease. APP comprises a large extracellular region, a single transmembrane helix and a short cytoplasmic tail containing an NPxY motif (normally referred to as ...
Charles Ellis +9 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Investissement en culture attelée et amélioration de la rentabilité de la culture cotonnière en Centrafrique [PDF]
, 2010 Investment in Animal Traction and Improvement of the Profitability of the Cotton Culture in the Central African Republic. The objective of this study is to appreciate the contribution of animal traction to the improvement of the profitability of the ...
Mbétid-Bessane, E.
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