Results 201 to 210 of about 835,613 (245)

Rethinking Obesity Prevention: A Call for Strategic and Operational Clarity. [PDF]

Curr Obes Rep
Ramos Salas X, Hussey B, Alberga AS, Kyle T, Small F.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Social determinants of oral health among adults in Saudi Arabia: a narrative review. [PDF]

Saudi Dent J
Alsaif MI.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Topics for implementation research: Implementation researchers' and practitioners' views in The Netherlands. [PDF]

Implement Sci Commun
van Nassau F, Driessen A, van Bodegom-Vos L, Walters BH, Ista E, Keijser W, van der Kleij-van der Sluis R, Welker G, Wensing M, Vis C.   +9 more
europepmc   +1 more source

African Development Review Vol 17 N°2 [PDF]

AfDB, Salami, Adeleke Oluwole
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Organ crosstalk and dysfunction in Sepsis: harnessing emerging biotechnologies for future breakthroughs

Annals of Intensive Care
Alexandre Pierre, Steve Lancel, Sebastien Preau   +2 more
doaj   +1 more source

Intervention Mapping: A Framework to Co-Design the ALAPAGE Programme to Simultaneously Improve Dietary Diversity and Physical Fitness Among Older People. [PDF]

Health Expect
Jacquemot AF, Bocquier A, Vinet A, Dubois C, Darmon N, Gélie FC, Féart C, Verger P, Danthony S, ALAPAGE Study Group.   +9 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source