Results 61 to 70 of about 13,822,898 (238)

Reference ranges for d-dimer levels in malaysian women in the three trimesters of pregnancy [PDF]

, 2019
Introduction: Plasma D-dimer levels rise progressively during pregnancy, so one cannot apply normal reference ranges, or the usual cut-off value (500ng/mL), for the exclusion of venous thromboembolism (VTE), in pregnant women.
Ali, Aishah, Mohmad Sallih, Nornattasa, Subbiah, Indhira, Jackson, Nicholas   +3 more
core  

DataSheet1_Pan-Cancer Analysis and Validation Reveals that D-Dimer-Related Genes are Prognostic and Downregulate CD8+ T Cells via TGF-Beta Signaling in Gastric Cancer.DOCX

, 2022
Background: Cancer is considered one of the most lethal diseases worldwide. Venous thromboembolism (VTE) is the second leading cause of death in cancer patients. As one of the most reproducible predictors of thromboembolism, the D-dimer level is commonly
Lijuan Wei (837941), Yi Sui (118031), Zhezhou Chen (12115677), Wenjing Long (12115680), Sansan Zhao (12115683), Lei Han (150108), Dakang Xu (326915), Yu Luan (3479750), Yiming Guan (10888875), Lin Lin (46073), Bing Xu (69508), Yan Jiang (12139), Qi Guan (1521055)   +12 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Significance of D-Dimer Levels in the Evaluation of Postoperative Muscular Calf Vein Thrombosis: A Restricted Cubic Spline Analysis

Clinical and Applied Thrombosis/Hemostasis
Background D-dimer have been frequently used to assess the preliminary risk of muscular calf vein thrombosis (MCVT) after knee arthroplasty. However, D-dimer is usually higher than the clinical reference range in clinical settings, the relationship ...
Honghui Zhang MS, Mengmeng Liu BSc, Qi Qin BSc, Aiqin Chu BSc, Lingyun Tian PhD   +4 more
doaj   +1 more source

Evaluation of Serum D-dimer Levels in Children with Pneumonia

, 2016
Aim: The aim of this study was to investigate the relationship of plasma D-dimer levels with duration of hospitalization and radiological and laboratory findings in patients with pneumonia. Methods: Forty-seven patients with pneumonia (31 boys and 16
Nilgün Selçuk Duru, Murat Elevli
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Super Formula for Soluble C-Type Lectin-Like Receptor 2 × D-Dimer in Patients With Acute Cerebral Infarction

Clinical and Applied Thrombosis/Hemostasis
Acute cerebral infarction (ACI) includes atherosclerotic and cardiogenic ACI and involves a thrombotic state, requiring antithrombotic treatment. However, the thrombotic state in ACI cannot be evaluated using routine hemostatic examinations.
Toshitaka Kamon MD, Hideo Wada MD, PhD, Shotaro Horie MD, Tomoya Inaba MD, Karin Okamoto MD, Katsuya Shiraki MD, PhD, Yuhuko Ichikawa, Minoru Ezaki, Motomu Shimaoka MD, PhD, Akisato Nishigaki MD, Akihiro Shindo MD, PhD, Hideto Shimpo MD, PhD, Nobuo Ito MD   +12 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Association of D-dimer and acute kidney injury associated with rhabdomyolysis in patients with exertional heatstroke: an over 10-year intensive care survey

Renal Failure, 2021
Patients with rhabdomyolysis (RM) following exertional heatstroke (EHS) are often accompanied by dysfunction of coagulation and acute kidney injury (AKI).
Conglin Wang, Baojun Yu, Ronglin Chen, Lei Su, Ming Wu, Zhifeng Liu   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source