Results 81 to 90 of about 13,822,898 (238)

Factors associated with D-dimer levels in HIV-infected individuals.

PLoS ONE, 2014
BackgroundHigher plasma D-dimer levels are strong predictors of mortality in HIV+ individuals. The factors associated with D-dimer levels during HIV infection, however, remain poorly understood.MethodsIn this cross-sectional study, participants in three ...
Alvaro H Borges, Jemma L O'Connor, Andrew N Phillips, Jason V Baker, Michael J Vjecha, Marcelo H Losso, Hartwig Klinker, Gustavo Lopardo, Ian Williams, Jens D Lundgren, INSIGHT SMART Study Group, ESPRIT Study Group, SILCAAT Scientific Committee   +12 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

D-Dimer in African Americans [PDF]

, 2017
Objective— Plasma levels of the fibrinogen degradation product D-dimer are higher among African Americans (AAs) compared with those of European ancestry and higher among women compared with men.
Rich, Stephen S, Cecelia Laurie, Duan, Qing, Peter Durda, Jerome I. Rotter, Rotter, Jerome I, Joshua D. Smith, Nickerson, Deborah A, Ethan M. Lange, Marguerite R. Irvin, Naik, Rakhi P, Adolfo Correa, Kenneth Rice, Jenny, Nancy S, Leslie A. Lange, Reiner, Alex P, Liu, Yongmei, Durda, Peter, Cushman, Mary, Irvin, Marguerite R, Smith, Joshua D, Andrew D. Johnson, Wilson, James G, Raffield, Laura M, Li, Yun, Yongmei Liu, Lange, Ethan M, Yun Li, Laurie, Cecelia, Zakai, Neil A, Manichaikul, Ani W, Stephen S. Rich, Rakhi P. Naik, Lange, Leslie A, Ani W. Manichaikul, Correa, Adolfo, Ci Song, Doyle, Margaret F, Mary Cushman, Alex P. Reiner, Neil A. Zakai, Rice, Kenneth, Song, Ci, Deborah A. Nickerson, Nancy S. Jenny, Laura M. Raffield, Qing Duan, Margaret F. Doyle, James G. Wilson, Johnson, Andrew D   +49 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

D-dimer identifies stages in the progression of diabetes mellitus from family history of diabetes to cardiovascular complications

, 2007
Aims The aim of the study was to ascertain whether there is variation in the fibrinolytic/coagulation component of diabetes associated with disease progression to macrovascular complications and whether D-dimer can discriminate such variation. Methods A
Jelinek, Herbert F., Nwose, Ezekiel U., Kerr, Philip G., Richards, Ross S.   +3 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Post-procedural plasma D-dimer level may predict futile recanalization in stroke patients with endovascular treatment

Journal of Stroke and Cerebrovascular Diseases
Objective: High d-dimer levels may increase the likelihood of unfavorable clinical outcomes in patients with acute ischemic stroke. However, the impacts of serum d-dimer levels on outcomes of reperfusion treatment in patients with acute ischemic stroke ...
Min Zhao, MD, Zhengze Dai, MD, Rui Liu, MD, Xinfeng Liu, MD, PhD, Gelin Xu, MD, PhD   +4 more
doaj   +1 more source