Results 91 to 100 of about 3,683,967 (228)

Exact optimal designs for weighted least squares analysis with correlated errors [PDF]

open access: yes, 2006
In the common linear and quadratic regression model with an autoregressive error structure exact D-optimal designs for weighted least squares analysis are determined.
Dette, Holger, Kunert, Joachim
core  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Comparing algorithms and criteria for designing Bayesian conjoint choice experiments. [PDF]

open access: yes
The recent algorithm to find efficient conjoint choice designs, the RSC-algorithm developed by Sándor and Wedel (2001), uses Bayesian design methods that integrate the D-optimality criterion over a prior distribution of likely parameter values ...
Goos, Peter   +2 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Low-power and area-efficient memristor based non-volatile D latch and flip-flop: Design and analysis.

open access: yesPLoS ONE
In recent years, non-volatile memory elements have become highly appealing for memory applications to implement a new class of storage memory that could replace flash memories in sequential logic applications, with features such as compactness, low power,
Haroon Rasheed S, Rajeev Pankaj Nelapati
doaj   +1 more source

An efficient algorithm for constructing Bayesian optimal choice designs. [PDF]

open access: yes
Recently, Kessels et al. (2006) developed a way to produce Bayesian G- and V-optimal designs for the multinomial logitmodel. These designs allow for precise response predictions which is the goal of conjoint choice experiments.
Goos, Peter   +3 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Time-Efficient and Practical Design Method for Skewed PMSMs: Integrating Numerical Calculations With Limited 3-D-FEA

open access: yesIEEE Open Journal of the Industrial Electronics Society
This article proposes a time-efficient and practical design method for determining appropriate skew structures for permanent magnet synchronous motors (PMSMs). Various PMSMs use skew to suppress torque ripple, but 3-D finite element analysis (3-D-FEA) is
Ren Tsunata   +3 more
doaj   +1 more source

Detection and Classification of Multiple Objects using an RGB-D Sensor and Linear Spatial Pyramid Matching

open access: yesELCVIA Electronic Letters on Computer Vision and Image Analysis, 2013
This paper presents a complete system for multiple object detection and classification in a 3D scene using an RGB-D sensor such as the Microsoft Kinect sensor.
Georgios Triantafyllidis   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

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