From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Promise of Evidence-Based Policymaking: Appendices E-H
, 2017 Supplementary appendices that support the final report of the Commission on Evidence-Based Policymaking including ..
United States. Commission on Evidence-Based Policymaking.
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Must Evidence Underdetermine Theory? [PDF]
, 2003 According to the underdetermination thesis, all evidence necessarily underdetermines any scientific theory. Thus it is often argued that our agreement on the content of mature scientific theories must be due to social and other factors. Drawing on a long
Norton, John D., Norton, John D
core
Gear Fault Diagnosis Method based on Multi-domain Feature and Improved D-S Evidence Theory
, 2019 In order to fully and accurately identify the fault category of gear，a feature space model based on multi-domain characteristic parameters such as time domain，frequency domain and energy is established.
Fang Liu, Yanxue Wang
core +1 more source
Bearing Fault Diagnosis using Multi-sensor Fusion based on weighted D-S Evidence Theory
, 2018 This paper has presented a novel method for bearing fault diagnosis using a multi-sensor fusion approach based on an improved weighted Dempster-Shafer (D-S) evidence theory combined with Genetic Algorithm (GA).
Lin Shuiquan (17923016) +4 more
core +5 more sources
Trusted routing based on D-S evidence theory in wireless mesh network
Tongxin xuebao, 2011 Combined with Dempster-Shafer（D-S） evidence theory,a trust evaluation model was given,meanwhile,a trusted routing——T-AODV was also proposed which built trusted routings according to the trustworthiness of nodes calculated by the proposed trust evaluation
YANG Kai, MA Jian-feng, YANG Chao
doaj +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
ECG Signal Classification Based on Fusion of Hybrid CNN and Wavelet Features by D-S Evidence Theory. [PDF]
J Healthc Eng, 2021 Zhang J +5 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source