Results 91 to 100 of about 42,834 (276)

Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats

Frontiers in Behavioral Neuroscience, 2014
Addiction is considered to be a brain disease caused by chronic exposure to drugs. Sensitization of brain dopamine (DA) systems partly mediates this effect. Pathological gambling (PG) is considered to be a behavioral addiction.
Martin eZack, Martin eZack, Robert E Featherstone, Sarah eMathewson, Paul J Fletcher   +4 more
doaj   +1 more source

Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin [PDF]

, 2018
Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase ...
Baucum, Anthony J., II, Edler, Michael C., Kaur, Harjot, Morris, Cameron W., Salek, Asma B., Watkins, Darryl S., Yamamoto, Bryan K.   +6 more
core   +1 more source

Patient‐reported outcomes for monitoring substance use treatment: A systematic review of single‐item measures

Addiction, EarlyView.
Abstract Background and aims Measurement‐based care (MBC) is a structured approach using standardized, repeated assessments to monitor treatment progress and guide clinical decision‐making. MBC improves outcomes for substance use treatment but can be time consuming due in part to lengthy assessment tools. Single‐item, patient‐reported outcome measures (
Thomas J. Reese, Hilary A. Tindle, Justin Bachmann, Adam Wright, Jessica S. Ancker, Carolyn M. Audet, Mauli V. Shah, Bryan D. Steitz, Michael H. Levin, Kristopher A. Kast, David Marcovitz, Amanda von Horn, A. Taylor Kelley, John F. P. Bridges   +13 more
wiley   +1 more source

Are people who use methamphetamine at increased risk of physical violence? Results from a nationally representative sample

Addiction, EarlyView.
Abstract Background and aims The association between methamphetamine use and violent behaviour has received much attention in the research. The risk of violent victimisation among people who use methamphetamine is comparatively underexplored. People who use methamphetamine appear to be at a high risk of violent victimisation, but no studies have ...
Christel Macdonald, Rebecca McKetin, Sergey Alexeev, Don Weatherburn   +3 more
wiley   +1 more source

The Effect of Effort: An analysis of Killeen's (1994) Mathematical Principles of Reinforcement [PDF]

, 2011
Mathematical Principles of Reinforcement (MPR, Killeen, 1994) is a mathematical model comprising three main concepts; an animal’s arousal to behaviour based on its motivation for a particular reinforcer, time and energy constraints on responding, and ...
Bjarnesen, Rebecca Claire
core   +1 more source

Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors. [PDF]

, 2016
The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a self-rewarding behavior exhibiting addictive properties.
Caetano-Anollés, Kelsey, Garland, Theodore, Hernandez, Alvaro G, Perez, Sam D, Rhodes, Justin S, Rodriguez-Zas, Sandra L, Southey, Bruce R   +6 more
core   +2 more sources

Factors associated with readmission to residential treatment among clients transitioned from detoxification services in Alberta, Canada

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Readmission to residential treatment increases healthcare costs, strains publicly funded systems, and may not adequately meet clients' needs. This study examined rates and predictors of readmission to residential treatment among clients transitioned from detoxification services.
Abreham Mekonnen
wiley   +1 more source

Rotating and Neurochemical Activity of Rats Lesioned with Quinolinic Acid and Transplanted with Bone Marrow Mononuclear Cells

Behavioral Sciences, 2018
Huntington’s disease (HD) is an inherited, neurodegenerative disorder that results from the degeneration of striatal neurons, mainly GABAergic neurons. The study of neurochemical activity has provided reliable markers to explain motor disorders. To
Teresa Serrano Sánchez, María Elena González Fraguela, Lisette Blanco Lezcano, Esteban Alberti Amador, Beatriz Caballero Fernández, María de los Ángeles Robinson Agramonte, Lourdes Lorigados Pedre, Jorge A Bergado Rosado   +7 more
doaj   +1 more source

Lisdexamfetamine dimesylate: A prodrug stimulant for the treatment of ADHD in children and adults [PDF]

, 2010
Attention-deficit/hyperactivity disorder (ADHD) is a highly genetic neuropsychiatric disorder that can cause impairment at school, work, home, and in social relationships.
Mattingly, Greg W
core   +2 more sources

Contact Activation Is Alleviated by Testosterone Replacement Therapy in Klinefelter Syndrome: Evidence of Hormonal and Metabolic Modulation

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome is associated with a markedly increased risk of venous thrombosis. While hypogonadism and metabolic dysfunction are known contributors, the role of the contact activation system in Klinefelter syndrome remains unexplored.
Simon Chang, Claus H. Gravholt, Anne Skakkebæk, Anna‐Marie Bloch Münster, Yaseelan Palarasah   +4 more
wiley   +1 more source