Results 81 to 90 of about 42,834 (276)

Effect of D-amphetamine on dopaminergic neurons of substantia nigra and expression of tyrosine hydroxylase in striatum and pre-frontal cortex of D-amphetamine treated Wistar rats

Russian Open Medical Journal, 2014
Dopaminergic neurons of the midbrain are the main source of dopamine in the mammalian central nervous system. Dopamine is a chemical messenger active in mesolimbic and mesocortical reward pathways.
Sarun Koirala, Sandip Shah, Laxman Khanal   +2 more
doaj   +1 more source

Duration judgements in patients with schizophrenia [PDF]

, 2003
Background. The ability to encode time cues underlies many cognitive processes. In the light of schizophrenic patients' compromised cognitive abilities in a variety of domains, it is noteworthy that there are numerous reports of these patients displaying
Brown, G. D. A. (Gordon D. A.), Elvevåg, Brita, Gilbert, A., Goldberg, Terry E., McCormack, Teresa, Weinberger, Daniel R. (Daniel Roy)   +5 more
core   +1 more source

High temporal resolution monitoring of illicit drug consumption across England via wastewater analysis

Addiction, EarlyView.
Abstract Aim To monitor community‐level consumption of 20 illicit drugs across urban areas of England using wastewater‐based epidemiology (WBE) surveillance at high temporal resolution. Design, setting, cases This study was conducted over a 12‐month period in 2022 sampling 24‐hour composite wastewater samples at 15 wastewater treatment plants (WWTPs ...
Helena Rapp‐Wright, Keng Tiong Ng, Derryn Grant, William Francis, Margarita White, Dimitris Evangelopoulos, Yuxing Liu, Konstantina Dimakopoulou, Sofia Zafeiratou, Dylan Wood, Chryshanthi Christy, Stav Friedman, Timothy W. Gant, Klea Katsouyanni, Leon P. Barron   +14 more
wiley   +1 more source

Differential effects of Δ9-tetrahydrocannabinol dosing on correlates of schizophrenia in the sub-chronic PCP rat model.

PLoS ONE, 2020
Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission.
Alexandre Seillier, Alex A Martinez, Andrea Giuffrida   +2 more
doaj   +1 more source

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Lisdexamfetamine prodrug activation by peptidase-mediated hydrolysis in the cytosol of red blood cells

Neuropsychiatric Disease and Treatment, 2014
Johannah Sharman, Michael Pennick Shire, Basingstoke, UK Abstract: Lisdexamfetamine dimesylate (LDX) is approved as a once-daily treatment for attention-deficit/hyperactivity disorder in children, adolescents, and adults in some countries.
Sharman J, Pennick M
doaj  

A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial.

PLoS ONE, 2015
Polydrug use is common, and might occur because certain individuals experience positive effects from several different drugs during early stages of use.
Margaret C Wardle, Benjamin A Marcus, Harriet de Wit   +2 more
doaj   +1 more source

Stimulant drug effects on attention deficit/hyperactivity disorder: a review of the effects of age and sex of patients [PDF]

, 2010
Objective: As dopamine functioning varies by sex and age it might be expected that the effects of methylphenidate or amfetamine, the psychostimulants used for the treatment of Attention Deficit /Hyperactivity Disorder (ADHD), will also be moderated by ...
Barke, Edmund, Coghill, David, Cornforth, Christine   +2 more
core   +1 more source

Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]

, 2018
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V, Burbach, Kyle F, Cameron, Lindsay P, Dennis, Megan Y, Duim, Whitney C, Gray, John A, Greb, Alexandra C, Ly, Calvin, McAllister, A Kimberley, Olson, David E, Ori-McKenney, Kassandra M, Paddy, Michael R, Soltanzadeh Zarandi, Sina, Sood, Alexander, Wilson, Paige C, Wong, Jonathan M   +15 more
core   +2 more sources

The association between sleep disturbance and stimulant use: A cross‐lagged examination

Addiction, EarlyView.
Abstract Background and aims Sleep disruptions increase the risk of substance misuse. Substance use—especially stimulants—can increase acute and chronic sleep dysfunction. This study aimed to estimate the associations between sleep disturbance and stimulant use over time among participants with stimulant use disorder (StUD).
Viviana E. Horigian, Renae D. Schmidt, Daniel J. Feaster, Rui Duan, Sophia T. Gonzalez, Kathryn Hefner, Dikla Shmueli‐Blumberg, Ashley Vena, Landhing M. Moran, Chloe A. DiCamillo, Shirin Shafazand, Susan Tross, Judith Feinberg   +12 more
wiley   +1 more source