Varenicline for cannabis use disorder: A randomized controlled trial
Addiction, EarlyView.Abstract Background and aims Although cannabis use is widespread and prevalence of cannabis use disorder (CUD) is increasing, limited advancements have been made in CUD medication development. The objective of this study was to test the efficacy of varenicline with medical management for reducing cannabis use in treatment‐seeking individuals with CUD ...
Aimee L. McRae‐Clark +8 more
wiley +1 more source
Changes over time in hallucinogen‐related emergency department visits in Ontario, Canada
Addiction, EarlyView.Abstract Background and aims Recent increasing interest in hallucinogens has underscored the critical gaps in our understanding of their adverse health effects and healthcare usage over time. The current study aimed to examine changes in emergency department (ED) visit rates involving hallucinogens, clinical outcomes of visits and the characteristics ...
Daniel T. Myran +9 more
wiley +1 more source
Neurobiology of Disease, 2020 Cerebral dopamine neurotrophic factor (CDNF) is neuroprotective for nigrostriatal dopamine neurons and restores dopaminergic function in animal models of Parkinson's disease (PD). To understand the role of CDNF in mammals, we generated CDNF knockout mice
Maria Lindahl +16 more
doaj +1 more source
Caffeine Versus Methylphenidate and d-Amphetamine in Minimal Brain Dysfunction: A Double-Blind Comparison [PDF]
, 1975 The authors compared the efficacy of caffeine, methylphenidate, and d-amphetamine in children with minimal brain dysfunction using a double-blind crossover design. The slight improvement with caffeine was not significantly better than placebo.
Arnold, L. Eugene +2 more
core
Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine [PDF]
, 2014 Peer reviewedPublisher ...
Anne-Sophie eDelbes +12 more
core +6 more sources
Regional perspectives: Substance use related problems in Ethiopia
Addiction, EarlyView.Abstract Ethiopia, with a population exceeding 130 million, presents a complex landscape for understanding substance use disorders. The country's diverse cultural heritage, varying regional practices, and evolving socioeconomic conditions create unique factors of substance use that differ markedly from global trends.
Tesfa M. Yimer +4 more
wiley +1 more source
Long-Term Stimulant Therapy and ADHD Outcome
Pediatric Neurology Briefs, 1997 The long-term effects of amphetamine sulfate (5 mg AM and lunchtime, increasing to a mean dose of 17 mg/d, 0.52 mg/kg body weight, and a maximum of 45 mg/d) were evaluated in 62 children, aged 6 to 11 years, with ADHD treated for 15 months in a ...
J Gordon Millichap
doaj +1 more source
Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists. [PDF]
PLoS ONE, 2011 Orexins are neuro-modulatory peptides involved in the control of diverse physiological functions through interaction with two receptors, orexin-1 (OX1R) and orexin-2 (OX2R).
Alessandro Gozzi +11 more
doaj +1 more source
Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]
, 2010 Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa +11 more
core +2 more sources
A call for action: Closing the evidence gap in management of stimulant‐induced psychosis
Addiction, EarlyView.Abstract Background Stimulant‐induced psychosis (StIP) is emerging as one of most pressing health challenges. Over the past two decades, stimulant‐related harms and psychiatric care demands have risen sharply. Individuals with StIP often present with severe agitation and high suicide risk, and up to half progress to chronic psychotic illness within two
Anne Bouthillier +3 more
wiley +1 more source