Results 71 to 80 of about 14,369,746 (295)

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

Effect of D-amphetamine on dopaminergic neurons of substantia nigra and expression of tyrosine hydroxylase in striatum and pre-frontal cortex of D-amphetamine treated Wistar rats

Russian Open Medical Journal, 2014
Dopaminergic neurons of the midbrain are the main source of dopamine in the mammalian central nervous system. Dopamine is a chemical messenger active in mesolimbic and mesocortical reward pathways.
Sarun Koirala, Sandip Shah, Laxman Khanal   +2 more
doaj   +1 more source

Transdiagnostic and symptom‐domain associations between mental illnesses and future self‐connectedness versus future self‐valence

JCPP Advances, EarlyView.
Abstract Background Future time perspective dimensions have been linked to various mental illnesses. Given the tendency for mental illnesses to co‐occur, it is necessary to disentangle associations between future‐oriented constructs and shared versus symptom‐domain‐specific psychopathology.
Yi Yang, Ingrid Obsuth, Jean‐Louis van Gelder, Denis Ribeaud, Manuel Eisner, Xinxin Zhu, Aja Louise Murray   +6 more
wiley   +1 more source

Differential effects of Δ9-tetrahydrocannabinol dosing on correlates of schizophrenia in the sub-chronic PCP rat model.

PLoS ONE, 2020
Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission.
Alexandre Seillier, Alex A Martinez, Andrea Giuffrida   +2 more
doaj   +1 more source

Effects of L-Amphetamine on the Central Neurons of the Snail

, 2009
The effects of l-amphetamine on the spontaneous firing of central neurons of African snails (Achatina fulica Ferussac) were studied electrophysiologically. The effects of dopamine, noradrenaline, d- amphetamine, and methamphetamine on the central neurons
Huang, Shiang-Suo; Chuang, Yao-Chin; Chen, Yi-Hung; Tsai, Ming-Cheng, 蔡明正   +1 more
core  

Mass Spectrometry in Authentication and Forensic Approaches for Determining the Origin of Hazardous Chemicals

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi, Grégoire Delaporte, Christine Albaret, Emmanuel Joubert, Anne Bossée, Emilien L. Jamin, Laurent Debrauwer   +6 more
wiley   +1 more source

Lisdexamfetamine prodrug activation by peptidase-mediated hydrolysis in the cytosol of red blood cells

Neuropsychiatric Disease and Treatment, 2014
Johannah Sharman, Michael Pennick Shire, Basingstoke, UK Abstract: Lisdexamfetamine dimesylate (LDX) is approved as a once-daily treatment for attention-deficit/hyperactivity disorder in children, adolescents, and adults in some countries.
Sharman J, Pennick M
doaj  

Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats

Frontiers in Behavioral Neuroscience, 2014
Addiction is considered to be a brain disease caused by chronic exposure to drugs. Sensitization of brain dopamine (DA) systems partly mediates this effect. Pathological gambling (PG) is considered to be a behavioral addiction.
Martin eZack, Martin eZack, Robert E Featherstone, Sarah eMathewson, Paul J Fletcher   +4 more
doaj   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial.

PLoS ONE, 2015
Polydrug use is common, and might occur because certain individuals experience positive effects from several different drugs during early stages of use.
Margaret C Wardle, Benjamin A Marcus, Harriet de Wit   +2 more
doaj   +1 more source