Results 51 to 60 of about 13,512,755 (196)

Effects of N-acetylcysteine on amphetamine-induced sensitization in mice

Brazilian Journal of Psychiatry, 2017
Objective: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled
Ana P. Herrmann, Roberta Andrejew, Radharani Benvenutti, Clarissa S. Gama, Elaine Elisabetsky   +4 more
doaj   +1 more source

Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice

Neurobiology of Disease, 2020
Cerebral dopamine neurotrophic factor (CDNF) is neuroprotective for nigrostriatal dopamine neurons and restores dopaminergic function in animal models of Parkinson's disease (PD). To understand the role of CDNF in mammals, we generated CDNF knockout mice
Maria Lindahl, Alcmène Chalazonitis, Erik Palm, Emmi Pakarinen, Tatiana Danilova, Tuan D. Pham, Wanda Setlik, Meenakshi Rao, Vootele Võikar, Jatta Huotari, Jaakko Kopra, Jaan-Olle Andressoo, Petteri T. Piepponen, Mikko Airavaara, Anne Panhelainen, Michael D. Gershon, Mart Saarma   +16 more
doaj   +1 more source

Reinforcing effects of d-amphetamine

, 2010
Progressive-ratio schedules are useful for studying the reinforcing effects of drugs. Earlier human laboratory studies showed that d-amphetamine significantly increased break points relative to placebo.
Glaser, Paul E. A., Sevak, Rajkumar J., William W. Stoops, Hays, Lon R., Rajkumar J. Sevak, Rush, Craig R., Stoops, William W., Paul E.A. Glaser, Lon R. Hays, Craig R. Rush   +9 more
core   +1 more source

Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333) [PDF]

, 2007
Amphetamine enhances recovery after experimental ischaemia and has shown promise in small clinical trials when combined with motor or sensory stimulation.
Sprigg, N, Pomeroy, VM, Gray, LJ, Willmott, MR, Pomeroy, Val, Walker, M, Gray, Laura J., Bath, Philip M.W., Bath, PMW, Willmot, Mark, Sunderland, Alan, Sprigg, Nikola, Walker, Marion   +12 more
core   +1 more source

Long-Term Stimulant Therapy and ADHD Outcome

Pediatric Neurology Briefs, 1997
The long-term effects of amphetamine sulfate (5 mg AM and lunchtime, increasing to a mean dose of 17 mg/d, 0.52 mg/kg body weight, and a maximum of 45 mg/d) were evaluated in 62 children, aged 6 to 11 years, with ADHD treated for 15 months in a ...
J Gordon Millichap
doaj   +1 more source

Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists. [PDF]

PLoS ONE, 2011
Orexins are neuro-modulatory peptides involved in the control of diverse physiological functions through interaction with two receptors, orexin-1 (OX1R) and orexin-2 (OX2R).
Alessandro Gozzi, Giuliano Turrini, Laura Piccoli, Mario Massagrande, David Amantini, Marinella Antolini, Prisca Martinelli, Nicola Cesari, Dino Montanari, Michela Tessari, Mauro Corsi, Angelo Bifone   +11 more
doaj   +1 more source

Effect of D-amphetamine on dopaminergic neurons of substantia nigra and expression of tyrosine hydroxylase in striatum and pre-frontal cortex of D-amphetamine treated Wistar rats

Russian Open Medical Journal, 2014
Dopaminergic neurons of the midbrain are the main source of dopamine in the mammalian central nervous system. Dopamine is a chemical messenger active in mesolimbic and mesocortical reward pathways.
Sarun Koirala, Sandip Shah, Laxman Khanal   +2 more
doaj   +1 more source

Differential effects of Δ9-tetrahydrocannabinol dosing on correlates of schizophrenia in the sub-chronic PCP rat model.

PLoS ONE, 2020
Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission.
Alexandre Seillier, Alex A Martinez, Andrea Giuffrida   +2 more
doaj   +1 more source

Lisdexamfetamine prodrug activation by peptidase-mediated hydrolysis in the cytosol of red blood cells

Neuropsychiatric Disease and Treatment, 2014
Johannah Sharman, Michael Pennick Shire, Basingstoke, UK Abstract: Lisdexamfetamine dimesylate (LDX) is approved as a once-daily treatment for attention-deficit/hyperactivity disorder in children, adolescents, and adults in some countries.
Sharman J, Pennick M
doaj  

Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats

Frontiers in Behavioral Neuroscience, 2014
Addiction is considered to be a brain disease caused by chronic exposure to drugs. Sensitization of brain dopamine (DA) systems partly mediates this effect. Pathological gambling (PG) is considered to be a behavioral addiction.
Martin eZack, Martin eZack, Robert E Featherstone, Sarah eMathewson, Paul J Fletcher   +4 more
doaj   +1 more source