Results 31 to 40 of about 42,834 (276)
Effects of amphetamine administration on neurogenesis in adult rats
Folia Neuropathologica, 2017 In our study expression of phospho-(Ser-10)-histone H3 (pH3S10), a marker for the early stage of neurogenesis, and cellular early response genes were investigated using c-Fos protein as an example of a transcription factor in the neurogenic process in ...
Tomasz Stępień +4 more
doaj +1 more source
Neuropsychopharmacology Reports, 2020 Aim To assess safety, tolerability, and pharmacokinetics of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adults. Methods A phase 1, double‐blind, randomized, placebo‐controlled, single‐ and multiple‐dose study in Japanese and Caucasian ...
James Ermer +3 more
doaj +1 more source
EJNMMI Radiopharmacy and Chemistry, 2016 Background Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. Here, we used [18F]JNJ42259152 PET
Maarten Ooms +11 more
doaj +1 more source
Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]
, 2017 RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M. +3 more
core +1 more source
Differential effects of MDMA and methylphenidate on social cognition [PDF]
, 2014 Social cognition is important in everyday-life social interactions. The social cognitive effects of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and methylphenidate (both used for neuroenhancement and as party drugs) are largely unknown.
Crockett, Molly J. +5 more
core +1 more source
PLoS ONE, 2015 Changes in endogenous dopamine levels can be detected in humans using positron emission tomography scans by measuring the amount by which a specific D2/3 radioligand is displaced.
Lora D Weidner +3 more
doaj +1 more source
The use of d-amphetamine pellet implantation as a model for d-amphetamine tolerance in the mouse [PDF]
Psychopharmacologia, 1973 The use of d-amphetamine pellet implantation as a method for producing rapid central drug tolerance was investigated. Mice were implanted with d-amphetamine pellets containing 2 mg of drug and were challenged 24 h later, a time when no detectable drug was present, with various doses of d-amphetamine i.p.
Craves, F. B. +3 more
openaire +3 more sources
Optimizing outcomes in ADHD treatment: From clinical targets to novel delivery systems [PDF]
, 2016 Our knowledge and understanding of the underlying neurobiology and symptomatic expression of ADHD has advanced dramatically over the past decade. Associated with these advances has been a similar explosion of new treatment options to individualize ...
Anderson, Richard H +1 more
core +2 more sources
Frontiers in Pharmacology, 2017 Marijuana is currently the most commonly abused illicit drug. According to recent studies, cannabinoid use occurring prior to pregnancy can impact brain plasticity and behavior in future generations.
George Panagis +3 more
doaj +1 more source
Modulation of mGlu2 Receptors, but Not PDE10A Inhibition Normalizes Pharmacologically-Induced Deviance in Auditory Evoked Potentials and Oscillations in Conscious Rats. [PDF]
PLoS ONE, 2016 Improvement of cognitive impairments represents a high medical need in the development of new antipsychotics. Aberrant EEG gamma oscillations and reductions in the P1/N1 complex peak amplitude of the auditory evoked potential (AEP) are neurophysiological
Abdallah Ahnaou +2 more
doaj +1 more source