Results 41 to 50 of about 14,369,746 (295)

Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). [PDF]

PLoS ONE, 2012
Both the subjective response to d-amphetamine and the risk for amphetamine addiction are known to be heritable traits. Because subjective responses to drugs may predict drug addiction, identifying alleles that influence acute response may also provide ...
Amy B Hart, Barbara E Engelhardt, Margaret C Wardle, Greta Sokoloff, Matthew Stephens, Harriet de Wit, Abraham A Palmer   +6 more
doaj   +1 more source

Reinforcing effects of d-amphetamine

, 2010
Progressive-ratio schedules are useful for studying the reinforcing effects of drugs. Earlier human laboratory studies showed that d-amphetamine significantly increased break points relative to placebo.
Glaser, Paul E. A., Sevak, Rajkumar J., William W. Stoops, Hays, Lon R., Rajkumar J. Sevak, Rush, Craig R., Stoops, William W., Paul E.A. Glaser, Lon R. Hays, Craig R. Rush   +9 more
core   +1 more source

Use of Lisdexamfetamine or Amphetamine? Interpretation of Chiral Amphetamine Analyses

, 2022
Amphetamine is frequently detected in forensic toxicological cases. Differentiating between the two isomers of amphetamine (d-amphetamine and l-amphetamine) and determining their relative proportion are fundamental to correctly interpret the results of ...
Jönsson, Anna K,, Cherma Yeste, Maria Dolores,, Ahlner, Johan,, Johansson, Anna,, Nilsson, Gunnel H.,   +4 more
core   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Effects of Sodium Azide, Barium Ion, d-Amphetamine and Procaine on Inward Rectifying Potassium Channel 6.2 Expressed in Xenopus Oocytes

Journal of the Formosan Medical Association, 2008
Background/Purpose: Inward rectifying potassium channel 6.2 (Kir6.2 Δ C26 channel) is closely related to ATP-sensitive potassium channels. Whether sodium azide, barium ion, d-amphetamine or procaine acts directly on the Kir6.2 Δ C26 channel remains ...
Fan-Lu Kung, Jung-Lung Tsai, Chien-Hsing Lee, Kuo-Long Lou, Chih-Yung Tang, Horng-Huei Liou, Kuan-Ling Lu, Yi-Hung Chen, Wun-Jheng Wang, Ming-Cheng Tsai   +9 more
doaj   +1 more source

Effect of ifenprodil and cyproheptadine treatments on the d-amphetamine-induced sensitization.

, 2016
Session 1: all groups received two saline administrations, 15 min and 30 min after being placed in the actimeter. Then, all amphetamine groups are treated with amphetamine (2 mg/kg) as indicated in materials and methods. Sessions 2 and 7: groups received
Alain Puech (3181143), Jean-Charles Bizot (188094), Philippe Bernard (1662010), Sabrina David (188082), Fabrice Trovero (3181146), Jean-Pol Tassin (3181149)   +5 more
core   +1 more source

Box plot of the effect of d-amphetamine (0.45 mg/kg, PO) and caffeine on Psychosis-like experiences (PLE).

, 2023
D-amphetamine but not caffeine significantly increased PLE scores, relative to placebo (p < 0.001). C: Caffeine, D: D-amphetamine, P: Placebo.
Sophie V. Slawik (16541968), Benjamin Peters (7730660), Katharina Gaus (47632), J. H. Mark Lim (16541965), Jennifer Rodger (299941), Joseph W. Y. Lee (16541971), Matthew A. Albrecht (626448), Faiz M. Kassim (16541962), Emily K. Hepple (16541974), Mathew T. Martin-Iverson (3125739)   +9 more
core   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source

Acute toxic leucoencephalopathy following protonitazene ingestion

British Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi, Holly Acton, Pierce Kavanagh, Isabelle Hunt, Niall Sheehy, Cormac Kennedy   +5 more
wiley   +1 more source