Results 61 to 70 of about 1,665,022 (280)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
ROLE OF VITAMIN D IN THE EFFICIENCY OF ANTIRESORPTIVE THERAPY
Современная ревматология, 2009 Vitamin D deficiency is one of the substantiated risk factors of osteoporosis. This vitamin is required to provide intestinal calcium absorption, bone metabolism regulation, and neuromuscular functions in the body.
N V Toroptsova
doaj +3 more sources
R&D Efficiency for Pharmaceutical Companies in the EU [PDF]
International journal of economics and statistics, 2013 This study constructs research and development (R&D) as a factor of productivity of European pharmaceutical industry. We introduce an empirical model derived from the Data Envelopment Analysis model to calculate R&D and efficiencies for selected European pharmaceutical companies.
Galović, Tomislav +2 more
openaire +1 more source
Measuring the change in R&D efficiency of the Japanese pharmaceutical industry – revised [PDF]
, 2006 This paper presents a DEA (Data Envelopment Analysis)/ Malmquist index methodology for measuring the R&D efficiency change of the Japanese pharmaceutical industry.Letting each of ten firms in each year be a separate DMU (Decision-Making Unit) and ...
Haneda Shoko +2 more
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By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Drawing blanks and winning: Quantifying global catastrophic risk associated with human ingenuity
Sustainable FuturesIn his Vulnerable World Hypothesis Nick Bostrom recently compared invention to drawing balls out of a giant urn containing at least one black ball (i.e. an invention that would destroy civilization).
John-Oliver Engler, Jan Niklas Fischer
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
The single-incision laparoscopic surgery technique has questionable advantages in colorectal surgery
Innovative Surgical Sciences, 2018 Laparoscopic procedures have increasingly been accepted as standard in surgical treatment of benign and malignant entities, resulting in a continuous evolution of operative techniques. Since one of the aims in laparoscopic colorectal surgery is to reduce
Schneider Bernd +3 more
doaj +1 more source
A dynamic analysis of regional R&D efficiency. The case of Italian and Spanish regions [PDF]
, 2013 Research and Development activities are key elements in the search of more productive economic outcomes, the generation of new economic sectors and, in general, of a better economic performance at the micro and macro levels.
AGUADO, Ricardo +2 more
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