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d-Galactose-induced accelerated aging model: an overview

Biogerontology, 2019
To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of D-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti ...
Khairunnuur Fairuz Azman   +1 more
openaire   +3 more sources

The p53/p21/p16 and PI3K/Akt signaling pathways are involved in the ameliorative effects of maltol on D‐galactose‐induced liver and kidney aging and injury

Phytotherapy Research, 2021
Successive evidence has established that maltol, a flavor‐enhancing agent, could provide resistance to oxidative stress‐induced tissue injury in various animal models though its benefits for aging‐induced liver and kidney injuries are still undetermined.
J. Sha   +9 more
semanticscholar   +1 more source

Phlorizin exerts potent effects against aging induced by D-galactose in mice and PC12 cells.

Food & Function, 2021
Phlorizin is the main active ingredient of apple peel and has potential utilization value. Some recent studies have suggested that phlorizin may have antioxidant capacity and protect the liver.
Yaojie Liu   +4 more
semanticscholar   +1 more source

Pentafluorophenylcorrole–d-galactose conjugates

Tetrahedron Letters, 2012
Abstract New corrole– d -galactose conjugates were synthesized from the reaction of 5,10,15-tris(pentafluorophenyl)corrole and 1,2:3,4-di-O-isopropylidene-α- d -galactopyranose. The monosubstituted isomers were fully characterized by NMR spectroscopy and mass spectrometry. The latter studies can be used to differentiate the two conjugate isomers. The
Teresa A.F. Cardote   +8 more
openaire   +1 more source

Astaxanthin attenuates d-galactose-induced brain aging in rats by ameliorating oxidative stress, mitochondrial dysfunction, and regulating metabolic markers.

Food & Function, 2020
Astaxanthin (AX) is a red-colored xanthophyll carotenoid with potent antioxidant, anti-inflammatory, and neuroprotective properties. However, the underlying in vivo mechanism by which AX protects the brain from oxidative stress remains unclear.
Han Liu   +6 more
semanticscholar   +1 more source

Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats.

Journal of Agricultural and Food Chemistry, 2019
Lycium ruthenicum Murr. (LR) is a perennial shrub commonly used as a nutritional food and medicine. Herein, we identified 12 anthocyanins from LR, with petunidin derivatives constituting approximately 97% of the total anthocyanin content.
Shasha Chen   +9 more
semanticscholar   +1 more source

A synthesis of phytosphingosines from D-galactose

Journal of the Chemical Society C: Organic, 1966
D-ribo-2-Amino-1,3,4-trihydroxyoctadecane (C18-phytosphingosine) and D-ribo-2-amino-1,3,4-trihydroxyeicosane (C20-phytosphingosine) have been synthesised by a Wittig reaction between 2,3,5-tri-O-benzyl-4-deoxy-4-phthalimidoaldehydo-L-ribose and the appropriate long-chain phosphorane.
J, Gigg, R, Gigg
openaire   +2 more sources

A specific method for d-galactose quantitative determination: A modification of the d-galactose oxidase assay

Carbohydrate Research, 1981
After treatment with D-galactose oxidase to form an aldehyde group, D-galactose or 2-acetamido-2-deoxy-D-galactose reacted with indole-hydrochloric acid to give a colored compound having a spectrum very similar to that of D-galacturonic acid, but with a maximum at 500 nm and a shoulder at 480 nm. The reaction is linear between 16.6 and 83 nmol of sugar
M E, Fernández de Recondo   +2 more
openaire   +2 more sources

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