Results 141 to 150 of about 15,326,315 (274)

Realizing the promise of ‘La Dolce Vita’ via chemical biology: glycan‐motif editing of sLeX for precision cancer therapeutics

open access: yesThe FEBS Journal, EarlyView.
Modification of the glycocalyx via ‘glycan editing’ is distinguishable from ‘glycan‐motif editing’. The former broadly remodels the glycocalyx, whereas the latter inhibits expression only of a specific oligosaccharide motif within the glycocalyx by selectively dampening the bioactivity of the key glycosyltransferase(s) programming the biosynthesis of ...
Barbara Richichi, Robert Sackstein
wiley   +1 more source

The gut‐microbiota‐brain axis: Focus on gut steroids

open access: yesJournal of Neuroendocrinology, EarlyView.
Abstract There are over 1000 varieties of steroids that have been reported in nature, including the endogenous sex steroid hormones (i.e., progesterone, testosterone, and 17β‐estradiol) and corticosteroids which are mainly synthesized by gonads and adrenals, respectively.
Silvia Diviccaro   +4 more
wiley   +1 more source

Dynamics of antibiotic resistance genes and the association with bacterial community during pig manure composting with chitin and glucosamine addition

open access: yesFrontiers in Microbiology
In modern ecological systems, the overuse and misuse of antibiotics have escalated the prevalence of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs), positioning them as emerging environmental contaminants.
Bo Wang   +21 more
doaj   +1 more source

Collagen Hydrolysates as Nutritional Support in Canine Osteoarthritis: A Narrative Review

open access: yesJournal of Animal Physiology and Animal Nutrition, Volume 109, Issue 2, Page 590-600, March 2025.
ABSTRACT Osteoarthritis (OA) is a common disease in dogs with severe impact on their welfare. The multimodal management of OA includes feeding therapeutic diets and nutraceuticals to slow down OA progression. Collagen hydrolysates (CH) are a nutritional supplement that may exert anabolic effects on osteoarthritic joint cartilage as well as disease ...
Niels R. Blees   +5 more
wiley   +1 more source

Characterization of GDP-mannose Pyrophosphorylase from Escherichia Coli O157:H7 EDL933 and Its Broad Substrate Specificity

open access: yes, 2005
GDP-mannose pyrophosphorylase gene (ManC) of Escherichia coli (E. coli) O157 was cloned and expressed as a highly soluble protein in E. coli BL21 (DE3). The enzyme was subsequently purified using hydrophobic and ion exchange chromatographies. ManC showed
Hwang, Bum-Yeol   +6 more
core  

A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum

open access: yesMolecular Microbiology, Volume 123, Issue 4, Page 330-343, April 2025.
In silico workflow for selection of genes targeted in this study. We have identified a number of proteins involved in host cell modification by malaria parasites. Furthermore, we highlight a number of genes that appear to be essential for blood‐stage survival of these parasites.
Nina Küster   +4 more
wiley   +1 more source

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