Results 201 to 210 of about 13,846,557 (251)

H3K18 Lactylation Promotes Cell Proliferation in T-Cell Acute Lymphoblastic Leukemia. [PDF]

J Cell Biochem
Feng L, Jin X, Zhang J, Zhai Z, Zhang X, Wang Y.   +5 more
europepmc   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

<i>In vitro</i> metabolic signaling in two intestinal bacterial isolates: glutamate-driven transcriptional and functional reprogramming in <i>Clostridium butyricum</i> and <i>Bacteroides thetaiotaomicron</i>. [PDF]

mSphere
Nematzadeh Somehsaraei N, Lemuel Hadi J, Khan Mirzaei M, Deng L, Gigl M, Dawid C, Schmitt-Kopplin P, Geydirici I, Schloter M, Gschwendtner S.   +9 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

The diversity of terminal electron acceptors across eukaryotes. [PDF]

Trends Biochem Sci
Midha AD, Jain IH.
europepmc   +1 more source

Tissue specific isoenzymes of d-lactate dehydrogenase from the foot, mantle and hepatopancreas of Patella caerulea (L). purification and properties

, 1990
LAZOU, A, MICHAELIDIS, B, PAPADOPOULOS, A   +2 more
core   +1 more source

Model‐informed optimal dose selection of golcadomide in combination with R‐CHOP in patients with previously untreated aggressive B‐cell lymphoma

British Journal of Clinical Pharmacology, EarlyView.
Aims Golcadomide is a potential first‐in‐class oral CELMoD™ agent for the treatment of lymphoma. This study aims to develop model‐informed drug development (MIDD) approaches to support optimal dose selection of golcadomide in combination with immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) in alignment with ...
Xirong Zheng, Zhiling Yu, Mark Kaplan, Argyrios Gkasiamis, Akshay Sudhindra, Li Zhu, Manisha Lamba, Fan Wu   +7 more
wiley   +1 more source

Inflammatory biomarkers as predictors of paradoxical reaction in tubercular meningitis: a prospective observational study. [PDF]

BMJ Neurol Open
Deswal S, Qavi A, Singh AK, Maurya PK, Kulshreshtha D, Ansari A.   +5 more
europepmc   +1 more source

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci, Carlotta Bidoli, Marco Gerdol, Charisse Winston, Robert A. Rissman, Giuliana Decorti, Antonella Fabretto, Andrea Taddio, Gabriele Stocco, Erik Roman‐Pognuz, Marianna Lucafò   +10 more
wiley   +1 more source

Lactate dehydrogenase-to-lymphocyte ratio predicts overall and progression-free survival among patients with advanced small-cell lung cancer receiving first-line chemoimmunotherapy: A two-center retrospective observational study. [PDF]

Medicine (Baltimore)
Hirose T, Teranishi S, Teranishi S, Kobayashi N, Tanaka A, Kajita Y, Kaneko A, Yamamoto M, Kudo M, Kaneko T.   +9 more
europepmc   +1 more source