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Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

open access: yesFrontiers in Pharmacology, 2023
Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases ...
Ki-Tae Ha   +2 more
exaly   +3 more sources

Characterization of a membrane-bound PQQ-dependent d-lactate dehydrogenase in Gluconobacter japonicus [PDF]

open access: yesApplied Microbiology and Biotechnology
Membrane-bound pyrroloquinoline quinone (PQQ)–dependent quinoproteins are key components of the periplasmic oxidative metabolism of acetic acid bacteria, yet several predicted enzymes remain experimentally uncharacterized.
Naoya Kataoka   +5 more
doaj   +2 more sources

Characterization of the L-lactate dehydrogenase from Aggregatibacter actinomycetemcomitans. [PDF]

open access: yesPLoS ONE, 2009
Aggregatibacter actinomycetemcomitans is a Gram-negative opportunistic pathogen and the proposed causative agent of localized aggressive periodontitis. A.
Stacie A Brown, Marvin Whiteley
doaj   +3 more sources

Elevated lactate dehydrogenase predicts pneumonia in spontaneous intracerebral hemorrhage

open access: yesHeliyon
Background: Although a variety of risk factors for pneumonia after spontaneous intracerebral hemorrhage have been established, an objective and easily obtainable predictor is still needed. Lactate dehydrogenase is a nonspecific inflammatory biomarker. In
Yangchun Xiao   +13 more
doaj   +2 more sources

Lactate Dehydrogenase

open access: yes, 2016
Abstract Glucose is transported into neurons and is used as an energy source. It is also transported into astrocytes and is converted to lactate, which is then released to neurons and is used as another energy source. The latter is called the astrocyte–neuron lactate shuttle.
Nagisa Sada, Tsuyoshi Inoue
openaire   +2 more sources

Mortality Prediction with Lactate and Lactate Dehydrogenase

open access: yes, 2015
It has been proved in many studies that Lactate and Lactate dehydrogenase (LDH) are associated with mortality. In this study lactate test values of inpatients were analyzed with Support Vector Machines (SVM) to identify patients in high risk of death.
Yasemin Zeynep Engin   +3 more
openaire   +3 more sources

Lactate Dehydrogenase

open access: yesRCSB Protein Data Bank, 2008
Bu ders notunda laktat dehidrogenaz enziminin üç boyutlu yapısı, koenzim ve kofaktörleri ile bazı özellikleri anlatılmaktadır.This lecture note is about the enzyme lactate dehydrogenase, its 3D structure, coenzymes and cofactors and some other ...
ERKOC, FIGEN
core   +3 more sources

Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma

open access: yesTumor Biology, 2017
Lactate dehydrogenase C is an isoenzyme of lactate dehydrogenase and a member of the cancer–testis antigens family. In this study, we aimed to investigate the expression and functional role of lactate dehydrogenase C and its basic mechanisms in renal ...
Yibo Hua   +12 more
doaj   +2 more sources

Biochemical and structural characterization of Cryptosporidium parvum Lactate dehydrogenase [PDF]

open access: yesInternational Journal of Biological Macromolecules, 2015
The protozoan parasite Cryptosporidium parvum causes waterborne diseases worldwide. There is no effective therapy for C. parvum infection. The parasite depends mainly on glycolysis for energy production.
Debasish Chattopadhyay   +2 more
exaly   +2 more sources

Utilizing the Lactate Dehydrogenase-to-Albumin Ratio for Survival Prediction in Patients with Neuroblastoma [PDF]

open access: yesChildren
Purpose: This study aimed to investigate the association between lactate dehydrogenase-to-albumin ratio (LAR) and the clinical characteristics and overall survival (OS) of patients with neuroblastoma (NB).
Suwen Li, Yue Ma, Shan Wang
doaj   +2 more sources

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