Results 21 to 30 of about 471,023 (292)

Activity of lactate dehydrogenase and superoxide dismutase in the circulation of patients with breast carcinoma [PDF]

Archive of Oncology, 2008
Background: A rapid increase in the turnover of malignant cells modulates the enzymes level in circulation and may be a prognostic sign of disease progression.
Bogdanović Gordana, Trajković Vesna, Jakimov Dimitar, Mrđanović Jasminka, Nikolić Aleksandra, Đorđević Milan, Turšijan Slavica, Bogdanović Višnja, Ivković-Kapicl Tatjana, Dugandžija Tihomir   +9 more
doaj   +1 more source

Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

Microbiome, 2022
Background Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the ...
Savannah J. Taylor, Maria G. Winter, Caroline C. Gillis, Laice Alves da Silva, Amanda L. Dobbins, Matthew K. Muramatsu, Angel G. Jimenez, Rachael B. Chanin, Luisella Spiga, Ernesto M. Llano, Vivian K. Rojas, Jiwoong Kim, Renato L. Santos, Wenhan Zhu, Sebastian E. Winter   +14 more
doaj   +1 more source

Glycerol dehydrogenase: Structure, specificity, and mechanism of a family III polyol dehydrogenase [PDF]

, 2001
Background: Bacillus stearothermophilus glycerol dehydrogenase (GlyDH) (glycerol:NAD+ 2-oxidoreductase, EC 1.1.1.6) catalyzes the oxidation of glycerol to dihydroxyacetone (1,3-dihydroxypropanone) with concomitant reduction of NAD+ to NADH.
Baker PJ, Sveta Sedelnikova, Taylor R, Sedelnikova S, Baker, Patrick J., Rice DW, Muir, Nicola M., Gore, Michael G., Burke J, David W. Rice, Ruzheinikov, Sergey N., Bullough, Per A., Sedelnikova, Sveta, Sergey N. Ruzheinikov, Per A. Bullough, Patrick J. Baker, Gore MG, Burke, Jacky, Michael G. Gore, Muir NM, Bullough PA, Nicola M. Muir, Rice, David W., Robert Taylor, Ruzheinikov SN, Jacky Burke, Taylor, Robert   +26 more
core   +1 more source

DETERMINATION OF DIAGNOSTIC ACCURACY OF BIOCHEMICAL PARAMETERS (CRP, LDH & FERRITIN) IN THE DIAGNOSIS OF COVID-19 IN SUSPECTED COVID CASES

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the diagnostic accuracy of the Lactate Dehydrogenase, C-Reactive Protein and Ferritin in suspected patients of COVID-19. Study Design: Cross-sectional validation study.
Tayyaba Ashiq, Abdus Sattar, Nasir Uddin, Qamar Bashir, Sajida Shaheen, Aamir Ijaz   +5 more
doaj   +3 more sources

The utility of lactate dehydrogenase in the follow up of patients with diffuse large B-cell lymphoma

Revista Brasileira de Hematologia e Hemoterapia, 2013
Background: Serum lactate dehydrogenase is a non-specific marker for lymphoma whose prognostic significance is well established for both indolent and aggressive lymphomas at the time of diagnosis.
Basem Magdy William, Navneeth Rao Bongu, Martin Bast, Robert Gregory Bociek, Philip Jay Bierman, Julie Marie Vose, James Olen Armitage   +6 more
doaj   +1 more source

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology [PDF]

, 2011
Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is
Vazquez, Alexei, Oltvai Zoltán N., Vazquez, A, Zoltán N Oltvai, Alexei Vazquez, Vazquez Alexei, Oltvai, ZN, Oltvai, Zoltán N., Zoltán N. Oltvai   +8 more
core   +2 more sources

Evidences of basal lactate production in the main white adipose tissue sites of rats. Effects of sex and a cafeteria diet.

PLoS ONE, 2015
Female and male adult Wistar rats were fed standard chow or a simplified cafeteria diet for one month. Then, the rats were killed and the white adipose tissue (WAT) in four sites: perigonadal, retroperitoneal, mesenteric and subcutaneous (inguinal) were ...
Sofía Arriarán, Silvia Agnelli, David Sabater, Xavier Remesar, José Antonio Fernández-López, Marià Alemany   +5 more
doaj   +1 more source

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Cell Reports, 2018
Summary: Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4).
Don Benjamin, Dimitri Robay, Sravanth K. Hindupur, Jens Pohlmann, Marco Colombi, Mahmoud Y. El-Shemerly, Sauveur-Michel Maira, Christoph Moroni, Heidi A. Lane, Michael N. Hall   +9 more
doaj   +1 more source

Conformational features of lactate dehydrogenase: temperature effect in presence of small molecules, mathematical model

Бюллетень сибирской медицины, 2020
The aim of this work was to study the conformational changes of lactate dehydrogenase under the influence of different concentrations of intermediates (pyruvate, oxaloacetate) in the temperature gradient with the  subsequent building of a mathematical ...
F. N. Gilmiyarova, V. I. Kuzmicheva, N. A. Kolotyeva, M. V. Komarova, E. A. Ryskina, O. A. Gusyakova, D. S. Vinogradova, V. V. Salmin   +7 more
doaj   +1 more source

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

Cell Reports, 2020
Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector
William J. Quinn, III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier   +22 more
doaj   +1 more source