Results 41 to 50 of about 471,023 (292)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Human D‐Lactate Dehydrogenase Deficiency: A Case Report in a Young Boy

JIMD Reports
D‐lactate is an isomeric form of lactate, which is almost undetectable in the circulation in individuals with normal lactate metabolism. Patients diagnosed with the disease human D‐lactate dehydrogenase deficiency present with elevated plasma D‐lactate ...
T. B. Sloth, M. C. Ørngreen, J. Ek, I. Bache, F. Wibrand, A. M. Lund   +5 more
doaj   +1 more source

SUBFRACTIONS OF LACTATE DEHYDROGENASE OF THE RAT [PDF]

Journal of Histochemistry & Cytochemistry, 1966
A survey of the lactate dehydrogenase (LDH) isozymes of 20 organs and tissues of the rat revealed a total of nine fractions exhibiting LDH activity after starch gel electrophoresis. Of the nine LDH fractions, eight were found in testis and lymph node, while the ninth fraction was unique to kidney.
J L, Buta, J L, Conklin, M M, Dewey
openaire   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Relative catalytic efficiencies and transcript levels of three d‐ and two l‐lactate dehydrogenases for optically pure d‐lactate production in Sporolactobacillus inulinus

MicrobiologyOpen, 2019
As the optical purity of the lactate monomer is pivotal for polymerization, the production of optically pure d‐lactate is of significant importance. Sporolactobacillus inulinus YBS1‐5 is a superior optically pure d‐lactate‐producing bacterium.
Bin Wu, Qi Yu, Shan Zheng, Marcelo Monteiro Pedroso, Luke W. Guddat, Bingfang He, Gerhard Schenk   +6 more
doaj   +1 more source

Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children. [PDF]

, 2014
The clinical course of rhinovirus (RV)-associated wheezing illnesses is difficult to predict. We measured lactate dehydrogenase concentrations, RV load, antiviral and proinflammatory cytokines in nasal washes obtained from 126 preschool children with RV ...
Cangiano, Giulia, Kaiser, Laurent, Tapparel, Caroline, Regamey, Nicolas, Barbani, Maria Teresa, Proietti, Elena, Alves, Marco P., Kieninger, Elisabeth, Sadeghi, Christine D, Alves, Marco P, Midulla, Fabio, Sadeghi, Christine D., Kronig, Marie Noelle, Gorgievski, Meri   +13 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Lactate dehydrogenase-to-albumin ratio for the severity of coronary artery disease in acute myocardial infarction: A retrospective study

Journal of International Medical Research
Objective This study aimed to explore the association between lactate dehydrogenase-to-albumin ratio and the severity of coronary artery disease in patients with acute myocardial infarction.
Haosheng Wu, Zhenyan Wu, Yu Xin, Xue Jiang, Caixia Guo   +4 more
doaj   +1 more source

The intensity of carbohydrate metabolism in the body of sows under the action of ferrum and germanium nanocompounds

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки
The article shows the influence of ferrum and germanium nanoparticles on the indicators of carbohydrate metabolism in sows' blood before and after farrowing.
O. O. Kovalchuk, V. A. Tomchuk, V. O. Danchuk, P. S. Khymynets, B. V. Gutyj, S. V. Kravchuk, O. V. Zhurenko, D. I. Kryvoruchko, V. V. Karpovskyi, P. V. Karpovskyi, V. B. Todoriuk, R. V. Hrelia, V. V. Zhurenko   +12 more
doaj   +1 more source