Results 111 to 120 of about 14,711,288 (261)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A loop closure approach for humanoids navigation, An approach to the loop closure problem, robust to severe view-point changes [PDF]
, 2013 A loop closure approach for humanoids navigation with visual-inertial data.\nThe approach is robust to severe view-point changes thanks to an estimation of view-point invariant frontal views of ...
Marostica, Michele
core
Closed-loop methodologies for cellular electrophysiology
, 2016 While the design of closed-loop experimental protocols in cellular electrophysiology dates back more than 60 years, recent developments promise to significantly advance the field.
Pulizzi R +7 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Structural Catalytic Core of the Members of the Superfamily of Acid Proteases
MoleculesThe superfamily of acid proteases has two catalytic aspartates for proteolysis of their peptide substrates. Here, we show a minimal structural scaffold, the structural catalytic core (SCC), which is conserved within each family of acid proteases, but ...
Alexander I. Denesyuk +3 more
doaj +1 more source
Sophie Doulut, The Land of the Rings
That day, as we were standing at the Galway Fort of the Ring,You folded your knee and offered me a handmade shiny ring,Not Queen Isolde’s emerald and antique gold token ring,That King Mark had twisted round her ring finger -Not THAT ring, Nor even ...
The LOOP team
core +1 more source
Closed loop identification based on quantization [PDF]
, 2002 This paper proposes a new closed-loop identification scheme for a single-input-single-output control loop. It is based upon a quantizer inserted into the feedback path. The quantizer can be used to generate an equivalent persistently exciting signal with
Huang, B, Wang, M, Thornhill, NF
core
Sophie Doulut, "Aladdin's Tree"
, 2023 Along the road stand crepe myrtles Bearing grapes of flowers Like so many jewels Gems of the sun and earth wed together. Their bright and vivid colors Light up the path of humans Who walk demurely and coyly Underneath them, Ignoring ...
The LOOP team
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source