Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Revista Chilena de Historia Natural, 2007 Existen cuatro especies de camélidos sudamericanos, dos de ellos silvestres, guanaco (Lama guanicoe) y vicuña (Vicugna vicugna), y dos formas domésticas, alpaca (Lama pacos) y llama (Lama glama), cuyo origen ha sido objeto de debate.
JUAN C MARÍN +10 more
doaj
Study of genetic diversity of wild Caspian trout Salmo trutta caspius in the Sardabrud and Astara Rivers, using D-Loop region sequencing [PDF]
, 2017 In this study the genetic diversity of wild Caspian trout (Salmo trutta caspius) in the Sardabroud and Astara Rivers was evaluated using D-Loop region sequencing.
Kamali, A. +3 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Keragaan Genetik Ikan Sidat (Anguilla Marmorata) Dari Perairan Poso Berdasarkan Polimorfisme Mitokondria Dna D-loop [Genetic Appearances of Eel (Anguilla Marmorata) From Poso Waters Based on Mitochondria Polymorphism Dna D-loop] [PDF]
, 2008 Anguilla marmorata is the dominant eel found in Poso. It has the largest body size and distributes on all habitat types especially the lake and the river of Poso. As catadromous fish, the larvae of eel grow in marine ecosystem which subsequently migrates
Lukman, N. (nFN) +2 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
陆军军医大学学报Objective To explore the specific mutations in mitochondrial genes of woman with unexplained complete early embryo development arrest in order to provide new data support for further elucidating the underlying mechanisms. Methods A case-control study was
YAO Xinyi +3 more
doaj +1 more source
ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences [PDF]
, 2004 A computer program, ARAGORN, identifies tRNA and tmRNA genes. The program employs heuristic algorithms to predict tRNA secondary structure, based on homology with recognized tRNA consensus sequences and ability to form a base-paired cloverleaf.
Laslett, D., Canback, B.
core +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations [PDF]
, 2014 Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by ...
Bartnik, Ewa +6 more
core +1 more source