Results 231 to 240 of about 716,794 (260)
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Demystifying the D-loop during DNA recombination
Nature, 2020Homologous recombination is a mechanism for DNA repair that enables the exchange of genetic information between DNA molecules. Structural analysis reveals how the protein RecA orchestrates this process. Structural data reveal how RecA protein orchestrates recombination.
Upasana Roy, Eric C. Greene
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Heterologous expression from the human D-Loop in organello
Mitochondrion, 2014We report the expression of a linear reporter construct in isolated human mitochondria. The reporter construct contained the entire human D-Loop with adjacent tRNA (MTT) genes (mt.15956-647), the human ND1 gene with an in frame GFP gene and adjacent endogenous MTT genes and heterologous rat MTT genes.
Jackson CB +3 more
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Molecular alterations of mitochondrial D‐loop in oral leukoplakia
Journal of Cellular Biochemistry, 2019AbstractBackgroundOver the years, numerous studies proposed a crucial role of mutations of nuclear DNA in the carcinogenesis process. Of late, many researchers suppose that alterations of mitochondrial DNA should not be excepted from this analysis. Mutational analysis of mitochondrial DNA displayed that mitochondrial D‐loop is assessed as a hotspot for
Azza Elamir +2 more
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Binding and Melting of D-Loops by the Bloom Syndrome Helicase
Biochemistry, 2000Bloom syndrome is a rare autosomal disorder characterized by predisposition to cancer and genomic instability. BLM, the structural gene mutated in individuals with the disorder, encodes a DNA helicase belonging to the RecQ family of helicases. These helicases have been established to serve roles in both promoting and preventing recombination.
A J, van Brabant +5 more
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Establishing the mitochondrial DNA D‐loop structure of Columba livia
ELECTROPHORESIS, 2009AbstractThe complete mitochondrial DNA D‐loop structure of pigeon (Columba livia) was established in this study. A strategy of amplifying three partial fragments of the D‐loop and then combing the three fragments to cover the full length of the D‐loop was adopted.
Tsai, L.C. +5 more
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A New Operation for d-Loop Transposition of the Great Vessels
The Annals of Thoracic Surgery, 1975Transposition of the great vessels remains a major problem for the cardiac surgeons. Although the Mustard (intraatrial baffle) procedure has provided the means for physiological correction of this anomaly, there are many complications that plague the lives of the survivors.
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Association of genetic variations in the mitochondrial D-loop with β-thalassemia
Mitochondrial DNA Part A, 2014Beta-thalassemia, one of the most common single-gene disorders, is the result of reduced or absent production of β-globin chains. Patients with β-thalassemia show weak genotype-phenotype correlations. Mitochondrial DNA polymorphisms are a potential source for different physiological and pathological characteristics and have been found to be associated ...
Leila, Jamali +4 more
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Polymorphic sequence in the D‐loop region of equine mitochondrial DNA
Animal Genetics, 1994SummaryThe D‐loop regions in equine mitochondrial DNA were cloned from three thoroughbred horses by polymerase chain reaction (PCR). The total number of bases in the D‐loop region were 1114bp, 1115bp and 1146bp. The equine D‐loop region is A/T rich like many other mammalian D‐loops.
N, Ishida +7 more
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A nuclear 'fossil' of the mitochondrial D-loop and the origin of modern humans
Nature, 1995Mammalian mitochondrial DNA sequences evolve more rapidly than nuclear sequences. Although the rapid rate of evolution is an advantage for the study of closely related species and populations, it presents a problem in situations where related species, used as outgroups in phylogenetic analyses, have accumulated so much change that multiple ...
Zischler, H. +3 more
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