Results 171 to 180 of about 13,643,061 (311)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

International Licensing and R&D Subsidy [PDF]

R&D rivalry and optimal R&D policies are investigated in an asymmetric four-stage game that involves international licensing. It is found that a government’s R&D policy crucially depends on its domestic firm’s bargaining power over the licensing gain ...
Cuihong Fan, Zhentang Zhang
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Overcoming Natural Resource Constraints Through R&D [PDF]

We study the optimal policies of research and development in the context of a resource-exploiting economy. We distinguish two cases: non-renewable resources and renewable resources.
Jean-Pierre Amigues, Ngo Van Long, Michel Moreaux   +2 more
core  

Application of a D-Optimal Mixture Design for the Development and Optimization of a Pasta Enriched With Pumpkin Products. [PDF]

J Food Sci
Oufighou A, Brahmi F, Achat S, Smail-Benazzouz L, Arroul Y, Slimani S, Saadi S, Boulekbache-Makhlouf L, Artés-Hernández F, Castillejo N.   +9 more
europepmc   +1 more source

Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evaluation in rabbits. [PDF]

Drug Deliv, 2022
Nemr AA, El-Mahrouk GM, Badie HA.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Sensory evaluation of instant noodles produced from blends of sweet potato, soybean and corn flour [PDF]

Food Research, 2019
Olorunsogo, S.T. , Adebayo, S.E. , Orhevba, B.A. , Awoyinka, T.B.   +3 more
doaj   +1 more source

Using a two-stage D-Optimal mode to select equipment for flexible manufacturing systems. [PDF]

Sci Rep
Yu X, Mi J, Liu J, Long L, Li X, Mo Q.
europepmc   +1 more source