Results 181 to 190 of about 13,643,061 (311)

Microwave-assisted Preparation of Cross-linked Gelatin-Paracetamol Matrices: Optimization Using the D-optimal Design [PDF]

Turk J Pharm Sci, 2021
Kuang TK, Kang YB, Segarra I, Kanwal U, Ahsan M, Bukhari NI.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Machine Learning Approach to the Optimal Execution Problem

, 2019
The Optimal Execution Problem has, for over a decade been of interest in financial mathematics. Solving the problem has, from the mathematics perspective involved using the dynamic programming principle in order to obtain a Hamilton-Jacobi-Bellman PDE to
Donahoe, Quinn
core  

Formulation and sensory evaluation of nutrient-dense complementary food mixes for infants and young children aligned with national nutritional standards in India: A D-optimal mixture design approach. [PDF]

Indian J Med Res
Thenarangam S, P S P, Vasireddy P, Vishnoi S, Shree S S, R C P, Epparapally S, Palika R, Madhari RS.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Remote Americium Detection Using an Optical Sensor: A D-Optimal Strategy for Efficient PLS-Based Modeling. [PDF]

Sensors (Basel)
Sadergaski LR, Einkauf JD, Pyles JM, Delmau LH, Burns JD.   +4 more
europepmc   +1 more source

Optimization of athletic pasta formulation by D-optimal mixture design. [PDF]

Food Sci Nutr, 2020
Kamali Rousta L, Ghandehari Yazdi AP, Amini M.   +2 more
europepmc   +1 more source

Valorisation of brewer's spent grain flour (BSGF) through wheat-maize-BSGF composite flour bread: optimization using D-optimal mixture design. [PDF]

Heliyon, 2022
Ginindza A, Solomon WK, Shelembe JS, Nkambule TP.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

D-optimal design model and biosynthetic pathway for gentamicin production by Micromonospora purpureochromogenes NRRL B-16094. [PDF]

BMC Microbiol
Suliman M, Bishr AS, Tohamy STK, Alshahrani MY, Aboshanab KM.   +4 more
europepmc   +1 more source