Results 61 to 70 of about 13,643,061 (311)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
D-OPTIMAL DESIGNS WITH ORDERED CATEGORICAL DATA
, 2017 Cumulative link models have been widely used for ordered categorical responses. Uniform allocation of experimental units is commonly used in practice, but often suffers from a lack of efficiency.
LP Tong (7937435) +2 more
core +1 more source
New Results Regarding the Construction Method for D‑optimal Chemical Balance Weighing Designs
Acta Universitatis Lodziensis. Folia Oeconomica, 2020 We study an experiment in which we determine unknown measurements of p objects in n weighing operations according to the model of the chemical balance weighing design. We determine a design which is D‑optimal. For the construction of the D‑optimal design,
Bronisław Ceranka, Małgorzata Graczyk
doaj +1 more source
On the growth problem for D-optimal designs
, 1997 When Gaussian elimination with complete pivoting (GECP) is applied to a real n×n matrix A, we will call g(n, A) the associated growth of the matrix. The problem of determining the largest growth g(n) for various values of n is called the growth problem. It seems quite difficult to establish a. value or close bounds for g(n). For specific values of n (n=
Mitrouli, M., Koukouvinos, C.
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Bayesian sequential D-D optimal model-robust designs. [PDF]
Alphabetic optimal design theory assumes that the model for which the optimal design is derived is usually known. However in real-life applications, this assumption may not be credible, as models are rarely known in advance.
Ruggoo, A, Vandebroek, Martina
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MetabolitesVitamin D is very important for bone metabolism as well as for the prevention of various diseases, such as type 2 diabetes, cardiovascular disease and different types of cancer.
Cem Ekmekcioglu, Michael Poteser
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
OPTIMAL EXPORT POLICY IN THE PRESENCE OF R&D INVESTMENT [PDF]
The purpose of this paper is to analyze the optimal export policy in a two-stage game in which a domestic and a foreign firm compete in price and R&D investment.
Tsuyoshi Toshimitsu
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