Results 81 to 90 of about 13,643,061 (311)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
On the number of support points of maximin and Bayesian D-optimal designs in nonlinear regression models [PDF]
We consider maximin and Bayesian D-optimal designs for nonlinear regression models. The maximin criterion requires the specification of a region for the nonlinear parameters in the model, while the Bayesian optimality criterion assumes that a prior ...
Dette, Holger, Braess, Dietrich
core
Low-value clinical practices in adult traumatic brain injury: an umbrella review protocol
BMJ Open, 2019 Introduction Traumatic brain injury (TBI) leads to 50 000 deaths, 85 000 disabilities and costs $60 billion each year in the USA. Despite numerous interventions and treatment options, the outcomes of TBI have improved little over the last three decades ...
Belinda J Gabbe +13 more
doaj +1 more source
D-optimal Saturated Designs: A Simulation Study [PDF]
, 2014 8 pages.
Fontana, Roberto +2 more
openaire +4 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Ain Shams Engineering Journal, 2018 In this paper, an approach for optimal placement of D-STATCOM in mesh distribution systems using sensitivity approaches is proposed. The main contributions of the paper are as follows: (i) Optimal D-STATCOM placement based on the new voltage sensitivity ...
Atma Ram Gupta, Ashwani Kumar
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
D-latch with optimal cost function in QCA technology
Results in EngineeringQuantum-dot cellular automata (QCA) is one of the new technologies in digital circuits and uses nano-sized cells. QCA technology has very high processing power, by placing these quantum cells next to each other, circuits can be designed that are smaller ...
Pezhman Kiani Vosta, Mohammad Gholami
doaj +1 more source
RANCANGAN D-OPTIMAL MODEL MICHAELIS MENTEN DAN EMAX DENGAN MATLAB
Media Statistika, 2015 Michaelis Menten and Emax models are widely used in chemistry, pharmacokinetics and pharmacodynamics areas. D-optimal criteria is criteria with the purpuse to minimize the variance of the estimator of parameters in the model. In this paper will discuss
Tatik Widiharih +3 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source